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Association of alcohol withdrawal severity with MTNR1A (rs34532313) and MTNR1B (rs10830963) genes polymorphisms

https://doi.org/10.52667/2712-9179-2021-1-2-111-116

Abstract

Alcohol withdrawal is the most threatening condition encountered in patients with alcohol use disorder. Our study aimed to investigate the association of alcohol withdrawal severity with polymorphic variants in melatonin receptor genes. Methods. The clinical study was carried out on the basis of the Republican Narcological Dispensary №1 in Ufa and the Republican Narcological Dispensary №2 in Sterlitamak. Genetic analysis was performed at the Department of Personalised Psychiatry and Neurology at the V.M. Bekhterev Research Centre, Saint Petersburg. The final sample consisted of 307 subjects. Results. Carriers of the TT genotype of the MTNR1A gene (rs34532313) were found to have less hypertension during alcohol withdrawal than carriers of the other genotypes. In comparison, carriers of the GG genotype of the MTNR1B gene (rs10830963) experienced more symptoms than other genotypes: paroxysmal sweating, visual hallucinations, anxiety, and overall CIWA-Ar score. Conclusions. Thus, it can be concluded that the TT genotype of MTNR1A gene (rs34532313) is associated with a lower risk of hypertension during alcohol withdrawal compared to carriers of other gene genotypes. The GG genotype of MTNR1B gene (rs10830963) is associated with severe withdrawal. In general, it can be concluded that melatonin receptors are involved in the pathogenesis of alcohol withdrawal and the severe of some of its symptoms.

 

About the Authors

I. S. Efremov
Bashkir State Medical University; Republican Clinical Psychiatric Hospital
Russian Federation

Ilia S. Efremov

450008 Ufa, 



D. R. Tukhvatullina
Barts and The London School of Medicine and Dentistry, Queen Mary University of London
United Kingdom

Dina R. Tukhvatullina

London



U. S. Efremova
Bashkir State Medical University
Russian Federation

Uliana S. Efremova

450008 Ufa



V. R. Gashkarimov
Bashkir State Medical University
Russian Federation

Vadim R. Gashkarimov

450008 Ufa



N. R. Tulbaeva
Republican Clinical Psychiatric Hospital
Russian Federation

Natalia R. Tulbaeva

450008 Ufa



E. A. Akhmetova
Bashkir State Medical University; Republican Narcological Dispensary No. 1
Russian Federation

Elvina A. Akhmetova

450008 Ufa,

450005 Ufa



T. R. Gizatullin
Republican Clinical Psychiatric Hospital
Russian Federation

Tagir R. Gizatullin

450008 Ufa



References

1. Grinevich, V.B.; Mekhtiev, S.N.; Uspenskij, Y.P.; Kravchuk, Y.A.; Barnakova, V.A.; Koblov, S.V. Methodological recommendations. Alcoholic Liver Disease. Part I: Alcoholic Hepatosis and Alcoholic Hepatitis: (clinic, diagnosis, principles of therapy); IntelTek: Petrozavodsk, Russia, 2004, 64.

2. Poplevchenkov, N.A. Alcohol problems in patients of general practitioners: identification, differentiated targeted intervention, prevention. Thesis of the doctoral dissertation, Moscow Research Institute of the Ministry of Health of the Russian Federation, Moscow, 03.07.2001.

3. Chernobrovkina, T.V.; Artemchuk, A.F.; Sosin, I.K.; Nikiforov, I.A. The problem of comorbidity and modern forms of alcoholic illness (clinical and pathogenetic aspect). Narcology 2006, 12, 45-74.

4. Efremov, I.S.; Asadullin, A.R.; Ahmetova, E.A. Association of insomnia and anxiety in people suffering from alcohol addiction. Topical Issues of Fundamental and Clinical Medicine : Proceedings of the Congress of Young Scientists. National Research Tomsk State University 19–20 November 2020, 381-383. doi:10.17816/nb18600.

5. Efremov, I.S.; Asadullin, A.R.; Nasyrova, R.F.; Akhmetova, E.A.; Yuldashev, V.L. Reseach of the association of suicidal behavior and sleep disorders in persons with alcohol addiction. Neurology Bulletin 2020, 52(2), 63-66. doi:10.17816/nb18600

6. McKeon, A; Frye, M.A.; Delanty, N. The alcohol withdrawal syndrome. J Neurol Neurosurg Psychiatry 2008, 79(8), 854-862. doi:10.1136/jnnp.2007.128322.

7. Salottolo, K.; McGuire, E.; Mains, C.W.; van Doorn, E.C. & Bar-Or, D. Occurrence, predictors, and prognosis of alcohol withdrawal syndrome and delirium tremens following traumatic injury. Critical Care Medicine 2017, 45(5), 867-874. doi:10.1097/CCM.0000000000002371.

8. Benedict, N. J.; Wong, A.; Cassidy, E.; Lohr, B.R.; Pizon, A.F.; Smithburger, P.L.; Falcione, B.A.; Kirisci, L.; Sandra, L.; Kane-Gill, S.L. Predictors of resistant alcohol withdrawal (RAW): a retrospective case-control study. Drug and Alcohol Dependence 2018, 192, 303-308. doi:10.1016/j.drugalcdep.2018.08.017.

9. Sachdeva, A.; Kumar, V.; Rizvi, S.A.A.; Khullar, S.; Abidi, S.S.A. & Das, A. Pattern of alcohol withdrawal syndrome and its clinical correlates. Biomedicine 2021, 41(2), 278-282. doi:10.51248/.v41i2.796.

10. Wood, E.; Albarqouni, L.; Tkachuk, S.; Green, C. J.; Ahamad, K.; Nolan, S.; McLean, M. & Klimas, J. Will this hospitalized patient develop severe alcohol withdrawal syndrome? : The rational clinical examination systematic review. JAMA 2018, 320(8), 825-833. doi:10.1001/jama.2018.10574.

11. Smith, A.H.; Ovesen, P.L.; Skeldal, S.; Yeo, S.; Jensen, K.P.; Olsen, D.; Diazgranados, N.; Zhao, H.; Farrer, L.A.; Goldman, D.; Glerup, S.; Kranzler, H.R.; Nykjær, A. & Gelernter, J. Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS 2. Alcoholism: Clinical and Experimental Research 2018, 42(12), 2337-2348. doi:10.1111/acer.13890.

12. Asadullin, A.R.; Efremov, I.S. Sleep disorders and alcohole abuse. Questions of Narcology 2019, 8, 44-44.

13. Asadullin, A.R.; Ahmetova, E.A., Efremov I.S. The role of sleep disorders and dysregulation of melatonin in formation of alcohol use disorders. Narcology 2020, 19(3), 66-75.. doi:10.25557/1682-8313.2020.03.66-75.

14. Efremov, I.S.; Asadullin, A.R.; Nasyrova, R.F.; Akhmetova, E.A.; Krupitsky, E.M. Alcohol and sleep disturbances. V.M. Bekhterev review of Psychiatry and Medical Psychology 2020, 3, 27-34. doi:10.31363/2313-7053-2020-3-27-34.


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For citations:


Efremov I.S., Tukhvatullina D.R., Efremova U.S., Gashkarimov V.R., Tulbaeva N.R., Akhmetova E.A., Gizatullin T.R. Association of alcohol withdrawal severity with MTNR1A (rs34532313) and MTNR1B (rs10830963) genes polymorphisms. Personalized Psychiatry and Neurology. 2021;1(2):111-116. https://doi.org/10.52667/2712-9179-2021-1-2-111-116

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