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Candidate genes of empty sella

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Empty sella (ES) is a condition characterized by arachnoid herniation into the sellar fossa which leads to flattening of the pituitary gland against the sellar floor. Besides endocrine disturbances, patients with ESS may also have neuropsychiatric symptoms such as headache, dizziness, seizures, schizophrenia. Typically, ES is not inherited. However, due to the advent of new methods of brain imaging and molecular genetics, the perspective on the genetics of ESS has been changing. The aim of this study is to analyze genome-wide association studies of candidate genes related to the development of ESS in humans. Based on the available studies which have been analyzed, all candidate genes of ESS were divided into 4 groups: group 1 - candidate genes related to ESS, group 2 - candidate genes related to pathways of ESS, group 3 - candidate genes related to cellular components of ESS, group 4 - candidate genes related to biological processes of ESS.

About the Authors

V. B. Sharavii
I.M. Sechenov First Moscow State Medical University
Russian Federation

Victoria B. Sharavii

119991, Moscow, tel.: +79940029712

N. A. Shnayder
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology; V. F. Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation

Natalia A. Shnayder

192019, St.Petersburg; 660022, Krasnoyarsk

M. M. Petrova
V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation

Marina M. Petrova

660022, Krasnoyarsk


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For citations:

Sharavii V.B., Shnayder N.A., Petrova M.M. Candidate genes of empty sella. Personalized Psychiatry and Neurology. 2021;1(1):46-53.

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