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Association of alcohol withdrawal severity with MTNR1A (rs34532313) and MTNR1B (rs10830963) genes polymorphisms

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Alcohol withdrawal is the most threatening condition encountered in patients with alcohol use disorder. Our study aimed to investigate the association of alcohol withdrawal severity with polymorphic variants in melatonin receptor genes. Methods. The clinical study was carried out on the basis of the Republican Narcological Dispensary №1 in Ufa and the Republican Narcological Dispensary №2 in Sterlitamak. Genetic analysis was performed at the Department of Personalised Psychiatry and Neurology at the V.M. Bekhterev Research Centre, Saint Petersburg. The final sample consisted of 307 subjects. Results. Carriers of the TT genotype of the MTNR1A gene (rs34532313) were found to have less hypertension during alcohol withdrawal than carriers of the other genotypes. In comparison, carriers of the GG genotype of the MTNR1B gene (rs10830963) experienced more symptoms than other genotypes: paroxysmal sweating, visual hallucinations, anxiety, and overall CIWA-Ar score. Conclusions. Thus, it can be concluded that the TT genotype of MTNR1A gene (rs34532313) is associated with a lower risk of hypertension during alcohol withdrawal compared to carriers of other gene genotypes. The GG genotype of MTNR1B gene (rs10830963) is associated with severe withdrawal. In general, it can be concluded that melatonin receptors are involved in the pathogenesis of alcohol withdrawal and the severe of some of its symptoms.


About the Authors

I. S. Efremov
Bashkir State Medical University; Republican Clinical Psychiatric Hospital
Russian Federation

Ilia S. Efremov

450008 Ufa, 

D. R. Tukhvatullina
Barts and The London School of Medicine and Dentistry, Queen Mary University of London
United Kingdom

Dina R. Tukhvatullina


U. S. Efremova
Bashkir State Medical University
Russian Federation

Uliana S. Efremova

450008 Ufa

V. R. Gashkarimov
Bashkir State Medical University
Russian Federation

Vadim R. Gashkarimov

450008 Ufa

N. R. Tulbaeva
Republican Clinical Psychiatric Hospital
Russian Federation

Natalia R. Tulbaeva

450008 Ufa

E. A. Akhmetova
Bashkir State Medical University; Republican Narcological Dispensary No. 1
Russian Federation

Elvina A. Akhmetova

450008 Ufa,

450005 Ufa

T. R. Gizatullin
Republican Clinical Psychiatric Hospital
Russian Federation

Tagir R. Gizatullin

450008 Ufa


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For citation:

Efremov I.S., Tukhvatullina D.R., Efremova U.S., Gashkarimov V.R., Tulbaeva N.R., Akhmetova E.A., Gizatullin T.R. Association of alcohol withdrawal severity with MTNR1A (rs34532313) and MTNR1B (rs10830963) genes polymorphisms. Personalized Psychiatry and Neurology. 2021;1(2):111-116.

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