Atypical Structure of Broca's Area in a Patient with Primary Progressive Atrophy Syndrome at the Onset of Alzheimer's Disease
https://doi.org/10.52667/10.52667/2712-9179-2024-4-1-2-17-9179-2024-4-1-32-40
Abstract
This article presents a clinical case of Alzheimer’s disease with a debut as primary progressive aphasia syndrome. Insufficient use of routine magnetic resonance imaging in this case in the diagnosis of neurodegenerative diseases and the advantage of such additional neuroimaging methods as positron emission tomography, functional magnetic resonance imaging with a scale assessment of atrophic changes. Additional neuroimaging techniques have been shown to significantly improve the early detection of pathological changes in brain structures and to reveal the location of functional areas involved in the neurodegenerative process.
About the Authors
Yu. V. KotsiubinskayaRussian Federation
Yulia V. Kotsiubinskaya
192019, Saint Petersburg
V. V. Vasilev
Russian Federation
Vladimir V. Vasilev
192019, Saint Petersburg
A. V. Kazakov
Russian Federation
Anton V. Kazakov
192019, Saint Petersburg
I. K. Stulov
Russian Federation
Ilya K. Stulov
192019, Saint Petersburg
V. A. Mikhailov
Russian Federation
Vladimir A. Mikhailov
192019, Saint Petersburg
References
1. Katsnelson, A.; De Strooper, B.; Zoghbi, H.Y. Neurodegeneration: From cellular concepts to clinical applications. Sci Transl Med. 2016;8(364):364ps18. DOI:10.1126/scitranslmed. aal2074
2. Preobrazhenskaya I.S. Dementia: epidemiology, clinical picture, diagnosis, approaches to therapy. Neurology, Neuropsychiatry, Psychosomatics. 2013; 5(4):71-77. (In Russ.) DOI: 10.14412/2074-2711-2013-2459
3. Yauzina, N.A.; Komleva, Yu.K.; Salmina, A.B.; Petrova, M.M.; Morozova, G.A.; Malinovskaya, N.A. Epidemiology of Alzheimer's disease in the world. Neurological Journal. 2012; 17(5): 32-37. (In Russ.)
4. Yakhno N.N., Preobrazhenskaya I.S., Zakharov V.V., Stepkina D.A., Lokshina A.B., Mkhitaryan E.A., Koberskaya N.N., Savushkina I.Yu. Prevalence of cognitive impairments in neurological diseases: Analysis of the activities of a specialized outpatient reception office. Neurology, Neuropsychiatry, Psychosomatics. 2012;4(2):30-35. (In Russ.) DOI: 10.14412/2074-2711-2012-378
5. Vasenina, E.E.; Levin, O.S.; Sonin, A.G. Modern trends in epidemiology of dementia and management of patients with cognitive impairment. Zhurnal Nevrologii I Psikhiatrii imeni S.S. Korsakova. 2017;117(6 2):87 95. (In Russ.)
6. DOI:10.17116/jnevro20171176287-95
7. Zakharov, V.V.; Lokshina, A.V.; Vakhnina, N.V. Combined therapy for Alzheimer's disease. Neurology, Neuropsychiatry, Psychosomatics. 2022;14(3):74-80. (In Russ.) DOI:10.14412/2074-2711-2022-3-74-80
8. Koberskaya, N.N. Alzheimer’s disease: new diagnostic criteria and therapeutic aspects depending on the stage of the disease. Medical Council. 2017;(10):18-24. (In Russ.) DOI:10.21518/2079-701X-2017-10-18-24
9. Belousov, Yu.B.; Zy`ryanov, S.K.; Belousov, D.Yu.; Beketov, A.S. Clinical and economic aspects of therapy for Alzheimer's disease in Russia. Quality clinical practice. 2009; S1:3-28.
10. Prince, M.; Ali, G.; Guerchet, M.; Prina, A. Matthew; Albanese, E.; Wu, Yu-Tzu. Recent global trends in the prevalence and incidence of dementia, and survival with dementia. Alzheimer's Research & Therapy. 2016;8(1):23. DOI:10.1186/s13195-016-0188-8
11. Rhodius-Meester, H.F.M.; Tijms, B.M.; Lemstra, A.W.; Prins, N.D.; Pijnenburg, Y.A.L.; Bouwman, F.; Scheltens, P.; van der Flier, W.M. Survival in memory clinic cohort is short, even in young-onset dementia. Journal of Neurology, Neurosurgery & Psychiatry. 2018; jnnp-2018-318820. DOI:10.1136/jnnp-2018-318820
12. Villain, N.; Dubois, B. Alzheimer's Disease Including Focal Presentations. Semin Neurol. 2019;39(2):213-226. DOI:10.1055/s-0039-1681041.
13. Braak, H.; Braak, E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991;82(4):239-59. DOI:10.1007/BF00308809
14. Marquié, M.; Siao Tick Chong, M.; Antón-Fernández, A.; Verwer, E.E.; Sáez-Calveras, N.; Meltzer, A.C.; Ramanan, P.; Amaral, A.C.; Gonzalez, J.; Normandin, M.D.; Frosch, M.P.; Gómez-Isla, T. [F-18]-AV-1451 binding correlates with postmortem neurofibrillary tangle Braak staging. Acta Neuropathologica. 2017;134(4):619-628. DOI:10.1007/s00401-017-1740-8.
15. De Carli, C.; Frisoni, G.B.; Clark, C.M., Harvey, D.; Grundman, M.; Petersen, V.; Thal, L. J.; Jin, S.; Jack, C. R.; Scheltens, P. Alzheimer's Disease Cooperative Study Group. Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia. Arch Neurol. 2007;64(1):108-15. DOI:10.1001/archneur.64.1.108.
16. Du, A.T.; Schuff, N.; Kramer, J.H.; Rosen, H.J.; Gorno-Tempini, M.L.; Rankin, K.; Miller, B. L.; Weiner, M. W. Different regional patterns of cortical thinning in Alzheimer’s disease and frontotemporal dementia. Brain. 2007;130 (Pt 4):1159-66. DOI:10.1093/brain/awm016.
17. Pyun, J.M.; Park, Y.H.; Kim, H.R.; Suh, J.; Min, Ju Kang, 1.; Beom Joon Kim, 1.; Youn, Y.C.; Jang, J.W.; Kim, S.Y. Posterior atrophy predicts time to dementia in patients with amyloid-positive mild cognitive impairment. Alzheimers Res Ther. 2017;9(1):99. DOI: 10.1186/s13195-017-0326-y.
18. Shi, F.; Liu, B.; Zhou, Y.; Yu, С.; Jiang, T. Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer’s Disease: Meta Analyses of MRI Studies. Hippocampus. 2009;19(11):1055-64. DOI:10.1002/hipo.20573.
19. Burke, S.L.; Rodriguez, M. J.; Barker, W.; Greig-Custo, M.T.; Rosselli, M.: Loewenstein, D.A.; Duara, R. Relationship between Cognitive Performance and Measures of Neurodegeneration among Hispanic and White Non-Hispanic Individuals with Normal Cognition, Mild Cognitive Impairment, and Dementia. J Int Neuropsychol Soc. 2018;24(2):176-187. DOI:10.1017/S1355617717000820.
20. Frisoni, G.B.; Prestia, A.; Zanetti, O.; Galluzzi, S.; Romano, M.; Cotelli, M.; Gennarelli, M.; Binetti, G.; Bocchio, L.; Paghera, B.; Amicucci, G.; Bonetti, M.; Benussi, L.; Ghidoni, R.; Geroldi, C. Markers of Alzheimer's disease in a population attending a memory clinic. Alzheimers Dement. 2009;5(4):307-17. DOI:10.1016/j.jalz.2009.04.1235
21. Karas, G.B.; Scheltens, P.; Rombouts, S.A.; Visser, P.J.; van Schijndel, W.; Fox, N C.; Barkhof, F. Global and local gray matter loss in mild cognitive impairment and Alzheimer’s disease. Neuroimaging. 2004;23: 708–716. DOI:10.1016/j.neuroimage.2004.07.006
22. Trivedi M.A., Wichmann A.K., Torgerson B.M., Ward M.A.; Schmitz, V.; Ries, Michele L.; Koscik, Rebecca L.; Asthana, S.; Sterling, C. Structural MRI discriminates individuals with Mild Cognitive Impairment from age-matched controls: A combined neuropsychological and voxel-based morphometry study. Alzheimers Dement. 2006;2(4):296-302. DOI: 10.1016/j.jalz.2006.06.001
23. Lehmann, M.; Rohrer, J.D.; Clarkson, M.J.; Ridgway, G.R.; Scahill, R.I.; Modat, M.; Warren, J.D.; Ourselin, S.; Barnes, J.; Rossor, M.N.; Fox, N. C. Reduced cortical thickness in the posterior cingulate gyrus is characteristic of both typical and atypical Alzheimer's disease. J Alzheimers Dis. 2010;20(2):587-98. DOI:10.3233/JAD-2010-1401.
24. Whitwell, J.L.; Jack, C.R.; Przybelski, S.A.; Parisi, J.E.; Senjem, M.L.; Boeve, B.F.; Knopman, D.S.; Petersen, R.C.; Dickson, D.W.; Josephs, K. A. Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis. Neurobiol Aging. 2011;32(9):1531-41. DOI: 10.1016/j.neurobiolaging.2009.10.012.
25. Emelin, A. Yu.; Odinak, M. M.; Trufanov, G. E.; Boykov, I. V.; Vorobiev, S.V.; Kashin, A.V.; Lobzin, V.Yu.; Kiselev, V.N.; Rezvantsev, M.V. Possibilities of positron emission tomography in the differential diagnosis of dementia. Bulletin of the Russian Military Medical Academy. 2010;4(32):46-51. (In Russ.)
26. Illarioshkin, S. N.; Vlasenko, A. G.; Fedotova, E. Yu. Modern opportunities for identifying the latent stage of the neurodegenerative process. Annals of Clinical and Experimental Neurology. 2013;7(2): 39-50. (In Russ.)
27. Litvinenko, I.V.; Emelin, A.Yu.; Lobzin, V.Yu.; Kolmakova K.A. Neuroimaging techniques for diagnosing Alzheimer’s disease and cerebrovascular diseases with cognitive impairment. Neurology, Neuropsychiatry, Psychosomatics. 2019;11(3S):18-25. (In Russ.) DOI:10.14412/2074-2711-2019-3S-18-25
28. Lobzin, V.Yu.; Kiselev, V.N.; Fokin, V.A.; Emelin, A.Yu.; Vorobyov, S.V.; Lupanov, I.A.; Sokolov, A.V.; Efimtsev, A.Yu. Application of magnetic resonance morphometry in the diagnosis of Alzheimer's disease and vascular cognitive impairment. Bulletin of the Russian Military Medical Academy. 2013;3(43):48-54. (In Russ.)
29. Anan’eva, N.I.; Lukina, L. V.; Andreev, E. V.; Tikhonov P. M. Gender features of normal age-related aging of the central nervous system. Database registration certificate 2021621983 dated 09/17/2021.
30. Madhavan, A.; Whitwell, J.L.; Weigand, S.D.; Duffy, J. R.; Strand, E. A.; Machulda, M. M.; Tosakulwong, N.; Senjem, M. L.; Gunter, J. L.; Lowe, V. J.; Petersen, R. C.; Jack Jr, C.R.; Josephs, K. A. FDG PET and MRI in logopenic primary progressive aphasia versus dementia of the Alzheimer’s type. PLoS One. 2013;8(4):e62471. DOI: 10.1371/journal.pone.0062471.
31. Mikhailov V.A.; Kotsiubinskaya Yu.V.; Safonova N.Yu.; Ananieva N.I.; Stulov I.K. Primary progressive aphasia. Neurology, Neuropsychiatry, Psychosomatics. 2019;11(1):4-11. DOI:10.14412/2074-2711-2019-1-4-11
Review
For citations:
Kotsiubinskaya Yu.V., Vasilev V.V., Kazakov A.V., Stulov I.K., Mikhailov V.A. Atypical Structure of Broca's Area in a Patient with Primary Progressive Atrophy Syndrome at the Onset of Alzheimer's Disease. Personalized Psychiatry and Neurology. 2024;4(1):32-40. https://doi.org/10.52667/10.52667/2712-9179-2024-4-1-2-17-9179-2024-4-1-32-40