Association of single nucleotide variants rs34532313 of the MTNR1A gene and rs10830963 of the MTNR1B gene with suicidal risk in alcohol dependence syndrome and insomnia
https://doi.org/10.52667/2712-9179-2022-2-1-73-80
Abstract
Background: Suicidal behaviour is the leading cause of mortality from external causes at all ages worldwide. More than a million people commit completed suicide each year. According to the World Health Organisation, 25-50% of suicide victims suffered from alcohol and other substance use disorders, 22% of all suicide deaths were attributable to alcohol use (WHO, 2014). Several papers have suggested potential associations of insomnia and increased suicide risk in patients with alcoholism. We hypothesise that mutations in melatonin receptor genes may be associated with suicide risk in patients with alcoholism.
Methods. The Insomnia Severity Index (ISI) was used as a tool to assess the presence and severity of insomnia. The Columbia Suicide Severity Rating Scale (C-SSRS) was used as a method to examine suicidal behavior. Genotyping of MTNR1A (rs34532313), MTNR1B (rs10830963) genes was performed using real-time polymerase chain reaction (RT-PCR). A comparative genetic study of two groups of patients was carried out: the first group, patients with alcohol dependence syndrome (F10.2); the second group, patients with alcohol dependence syndrome (F10.2) and insomnia, which persisted 7-14 days after starting alcohol withdrawal therapy.
Results. Suicidal thoughts and a history of auto-aggressive behaviour were more common in subjects with insomnia in the post-withdrawal period. Carriers of the TT genotype of the MTNR1A gene (rs34532313) were more likely to have suicidal thoughts and a history of suicide attempts in a genetic study of patients with insomnia.
Conclusions. Our study found that the TT genotype of the MTNR1A gene (rs34532313) is a genetic marker of suicidal behaviour risk in patients with insomnia in the post-withdrawal period. However, the same pattern was not observed in patients without insomnia.
Supporting agencies: This research received no external funding
About the Authors
I. S. Efremov
The Center of Personalized Psychiatry and Neurology, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology; The Bashkir State Medical University
Russian Federation
Russian Federation
Ilya S. Efremov
192019, Saint-Petersburg; 450008, Ufa
A. R. Asadullin
The Center of Personalized Psychiatry and Neurology, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology; The Bashkir State Medical University
Russian Federation
Russian Federation
Azat R. Asadullin
192019, Saint-Petersburg; 450008, Ufa
E. A. Akhmetova
The Center of Personalized Psychiatry and Neurology, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology; The Bashkir State Medical University
Russian Federation
Russian Federation
Elvina A. Akhmetova
192019, Saint-Petersburg; 450008, Ufa
L. R. Migranova
Republic of Bashkortostan Federal Budgetary Health Care Facility Children’s Polyclinic Number 6 of City of Ufa
Russian Federation
Russian Federation
Leisian R. Migranova
450015, Ufa
V. L. Yuldashev
The Bashkir State Medical University
Russian Federation
Russian Federation
Vladimir L. Yuldashev
450008, Ufa
N. A. Marfina
The Bashkir State Medical University
Russian Federation
Russian Federation
Natalia A. Marfina
450008, Ufa
E. R. Kunafina
The Bashkir State Medical University
Russian Federation
Russian Federation
Elena R. Kunafina
450008, Ufa
M. N. Gilmiyarova
The Bashkir State Medical University
Russian Federation
Russian Federation
Margarita N. Gilmiyarova
450008, Ufa
D. H. Kalimullina
The Bashkir State Medical University
Russian Federation
Russian Federation
Dilara H. Kalimullina
450008, Ufa
S. U. Tuktarova
The Bashkir State Medical University
Russian Federation
Russian Federation
Svetlana U. Tuktarova
450008, Ufa
E. Y. Sidorova
The Bashkir State Medical University
Russian Federation
Russian Federation
Evgeniya Y. Sidorova
450008, Ufa
V. S. Dobrodeeva
The Center of Personalized Psychiatry and Neurology, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology
Russian Federation
Russian Federation
Vera S. Dobrodeeva 1
192019, Saint-Petersburg; Tel.: + 7 (812) 620-02-20 78-13
R. F. Nasyrova
The Center of Personalized Psychiatry and Neurology, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology; Samara State Medical University
Russian Federation
Russian Federation
Regina F. Nasyrova
192019, Saint-Petersburg; Samara, 443099; Tel.: + 7 (812) 620-02-20 78-13
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For citations:
Efremov I.S., Asadullin A.R., Akhmetova E.A., Migranova L.R., Yuldashev V.L., Marfina N.A., Kunafina E.R., Gilmiyarova M.N., Kalimullina D.H., Tuktarova S.U., Sidorova E.Y., Dobrodeeva V.S., Nasyrova R.F. Association of single nucleotide variants rs34532313 of the MTNR1A gene and rs10830963 of the MTNR1B gene with suicidal risk in alcohol dependence syndrome and insomnia. Personalized Psychiatry and Neurology. 2022;2(1):73-80. https://doi.org/10.52667/2712-9179-2022-2-1-73-80
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