The Role of MicroRNAs as Crucial Regulators of Sleep /Wakefulness in Neurological and Mental Disorders (Systematic Review)
https://doi.org/10.52667/2712-9179-2025-5-4-3-15
Abstract
Sleep quality disorders in patients with neurological diseases are a common comorbid pathology that leads to mutual aggravation syndromes, accelerating the progression and severity of neurological conditions. Sleep problems speed up the progression of neurological diseases. In turn, these diseases further reduce sleep quality, this creates a “vicious cycle”. The prediction and early diagnosis of sleep quality disorders in patients with neurological profiles require the development of new sensitive and specific biomarkers. Among them, microRNA patterns are the most promising. This report will present the results of preclinical and clinical studies on changes in microRNA expression and their association with sleep quality disorders in experimental animals and humans with various neurological diseases and mental disorders. Additionally, a new personalized approach to assessing the risk of sleep quality disorders in patients with neurological and psychiatric profiles will be presented. This approach evaluates the risk of sleep disorders (low, medium, or high) based on the most thoroughly studied microRNA patterns.
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Review
For citations:
Seitkazina K. The Role of MicroRNAs as Crucial Regulators of Sleep /Wakefulness in Neurological and Mental Disorders (Systematic Review). Personalized Psychiatry and Neurology. 2025;5(4):3-15. https://doi.org/10.52667/2712-9179-2025-5-4-3-15
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