Monocyte-to-Lymphocyte Ratio Any Association with Metabolic Syndrome in Schizophrenia
https://doi.org/10.52667/2712-9179-2025-5-1-27-31
Abstract
The problem of adverse drug reactions (ADR) development in psychopharmacotherapy is one of the current issues in the treatment of patients with schizophrenia. One of the most common ADRs when taking antipsychotics is the development of metabolic syndrome. This reduces the quality of life of patients and increases the risk of premature death of patients due to cardiovascular diseases. Markers of systemic inflammation are a predictor of the development of metabolic syndrome in patients with schizophrenia. One of these hematological coefficients is the monocyte-to-lymphocyte ratio (MLR). Objective: to conduct a systematic review of scientific publications based on the relationship between MLR and metabolic syndrome in patients with schizophrenia. Methods: The initial search identified 120 articles from the Pubmed and ScienceDirect databases. The inclusion criterion for the study is the relationship between the MLR and metabolic syndrome in patients with schizophrenia. Result: Screening did not yield any publications suitable for systematic review.
Keywords
monocyte-to-lymphocyte ratio (MLR),
schizophrenia,
metabolic syndrome,
hematologic inflammation coefficients (HICs),
systemic inflammation,
psychiatric disorders,
immune dysregulation,
biomarkers,
antipsychotic therapy,
psychoneuroimmunology
Supporting agencies: The study was performed within the framework of the state assignment of the”Bekhterev’s National Medical Research Center For Psychiatry and Neurology of the Ministry of Health of Russia” (XSOZ 2024 0012).
About the Authors
N. V. Zakharova
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology
Russian Federation
Russian Federation
Natalia V. Zakharova
192019 Saint Petersburg
A. V. Kidyaeva
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology
Russian Federation
Russian Federation
Alla V. Kidyaeva
192019 Saint Petersburg
V. V. Grechkina
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology
Russian Federation
Russian Federation
Violetta V. Grechkina
192019 Saint Petersburg
I. R. Boyko
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology
Russian Federation
Russian Federation
Irina R. Boyko
192019 Saint Petersburg
A. I. Rakhmatullin
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology
Russian Federation
Russian Federation
Artyom I. Rakhmatullin
192019 Saint Petersburg
M. V. Tabak
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology
Russian Federation
Russian Federation
Mariia V. Tabak
192019 Saint Petersburg
R. F. Nasyrova
V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology
Russian Federation
Russian Federation
Regina F. Nasyrova
192019 Saint Petersburg
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Review
For citations:
Zakharova N.V., Kidyaeva A.V., Grechkina V.V., Boyko I.R., Rakhmatullin A.I., Tabak M.V., Nasyrova R.F. Monocyte-to-Lymphocyte Ratio Any Association with Metabolic Syndrome in Schizophrenia. Personalized Psychiatry and Neurology. 2025;5(1):27-31. https://doi.org/10.52667/2712-9179-2025-5-1-27-31
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