Neutrophil-to-Lymphocyte Ratio Any Association with Metabolic Syndrome in Schizophrenia
https://doi.org/10.52667/2712-9179-2024-4-3-12-23
Abstract
To date, hematologic inflammation coefficients (HICs) have been considered as biological markers linking the functions of the immune, endocrine, and autonomous nervous systems. HICs are markers of immune abnormalities that accompany various pathologic conditions and, to a large extent, determine disease prognosis, survival time, and function. According to the results of a meta-analysis covering the results of examination of more than 168 thousand patients, it was found that the ratio of neutrophils to lymphocytes (NLR) is associated with higher levels in patients with metabolic syndrome and can potentially be used for early detection of this pathology. Given these facts, it seems reasonable to test the assumption of the role of HICs in the pathogenesis of psychiatric disorders, their participation in the mechanisms of development of comorbid conditions, or predicting the outcome and effects of therapy. In 2024, the team of the Bekhterev Center began to perform work under the state assignment of the Ministry of Health of the Russian Federation, the purpose of which was to develop and validate a model for predicting individual risks of metabolic disorders in patients with psychiatric disorders, on the basis of which interpretive software will be presented. The team of authors of this article focused on conducting a systematic review of publications to test this hypothesis.
Keywords
neutrophil-to-lymphocyte ratio (NLR),
schizophrenia,
metabolic syndrome,
hematologic inflammation coefficients (HICs),
systemic inflammation,
psychiatric disorders,
immune dysregulation,
biomarkers,
antipsychotic therapy,
psychoneuroimmunology
Supporting agencies: The authors are grateful to the administration and management of the V. M. Bekhterev National Medical Research Centre for Psychiatry and Neurology and also thank the Director of the Centre, Scientific Head of the Geriatric Psychiatry Department of the Centre, Doctor of Medical Sciences, Professor N. G. Neznanov for the opportunity to conduct this project.
About the Authors
N. V. Zakharova
V. M. Bekhterev National Medical Research Center for Psychiatry and Neurology
Russian Federation
Russian Federation
Natalia V. Zakharova
192019 Saint Petersburg
R. F. Nasyrova
V. M. Bekhterev National Medical Research Center for Psychiatry and Neurology
Russian Federation
Russian Federation
Regina F. Nasyrova
192019 Saint Petersburg
A. I. Rakhmatullin
V. M. Bekhterev National Medical Research Center for Psychiatry and Neurology
Russian Federation
Russian Federation
Artyom I. Rakhmatullin
192019 Saint Petersburg
M. N. Rumiantceva
St. Nicholas Psychiatric hospital
Russian Federation
Russian Federation
Maria N. Rumiantceva
190121 Saint Petersburg
K. I. Sizykh
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Kirill I. Sizykh
197341 Saint Petersburg
F. N. Kostin
Russian Federation
Fedor N. Kostin - Independent researcher
Saint Petersburg
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Zakharova N.V., Nasyrova R.F., Rakhmatullin A.I., Rumiantceva M.N., Sizykh K.I., Kostin F.N. Neutrophil-to-Lymphocyte Ratio Any Association with Metabolic Syndrome in Schizophrenia. Personalized Psychiatry and Neurology. 2024;4(3):12-23. https://doi.org/10.52667/2712-9179-2024-4-3-12-23
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