The Personalized Algorithm of the “Tension-Type Headache and Arterial Hypertension” Phenotype Diagnosis
https://doi.org/10.52667/2712-9179-2023-3-1-53-58
Abstract
The tension-type headache (TTH) and arterial hypertension (AH) are one of the most common conditions worldwide. The cumulative assessment of clinical and genetic predictors needs to be revised. The aim is designing a scale and algorithm for predicting the risk of the “TTH + AH” phenotype developing in outpatient clinics. The leading non-genetic predictors are emotional lability and personal uneasiness. The leading genetic predictor is the carriage of the minor T allele and the heterozygous CT genotype rs3782218, as well as heterozygous genotype GA rs7314935 of the NOS1 gene encoding neuronal nitric oxide synthase. There are scale and personalized algorithm for assessing the risk of the “TTH + AH” phenotype development. There is the higher the score, the higher the risk of “TTH + AH” phenotype development in hypertensive patients. The using of the presented scale and algorithm will allow timely identification of a risk group for the “TTH + AH” phenotype and avoid diagnostic errors.
About the Author
P. V. Alyabyeva
Shared Core Facilities Molecular and Cell Technologies, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Polina V. Alyabyeva
Krasnoyarsk
Tel.: +7 (391) 228-06-28
References
1. Alyabyeva, P.V., Chastina, O.V., Shnayder, N.A., Petrova, M.M., Nasyrova, R.F. Tension-type headache and hypertension phenotype: myth or reality. The Siberian Journal of Clinical and Experimental Medicine 2022; 37(3): 29–40. (In Russian). DOI: 0.29001/2073-8552-2022-37-3-29-40
2. Petrova, M.M., Moskaleva, P.V., Shnayder, N.A., Nasyrova, R.F. Comorbidity of arterial hypertension and tension-type headache. Cardiology. 2020; 60: 132–140. (In Russian). DOI: 10.18087/cardio.2020.10.n1363
3. Olesen, J., Dodick, D.W., Ducros, A., Evers, S., First, M.B., Goadsby, P.J. The International Classification of Headache Disorders. Cephalalgia 2018; 38: 1–211. DOI: 10.1177/0333102417738202
4. Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D.L., Coca, A., De Simone, G., Dominiczak, A. et al. ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. Hypertens 2018; 36: 1953–2041. DOI: 10.1093/eurheartj/ehy339
5. Kobalava, Z.D., Konradi, A.O., Nedogoda, S. V., Shlyakhto, E. V., Arutyunov, G.P., Baranova, E.I., Barbarash, O.L., Boitsov, S.A., Vavilova, T. V., Villevalde, S. V. et al. Arterial hypertension in adults. Clinical guidelines. Russ. J. Cardiol. 2020; 25: 3786
6. Mantrova, I. N. Methodological guidance on psychophysiological and psychological diagnostics. Ivanovo: Neurosoft. 2007; 216.
7. Shnayder, N., Petrova, M., Moskaleva, P., Shesternya, P., Pozhilenkova, E., Nasyrova, R. The Role of single-nucleotide variants of NOS1, NOS2, and NOS3 genes in the comorbidity of arterial hypertension and tension-type headache. Molecules. 2021; 26: 1556. DOI: 10.3390/molecules26061556
8. Alyabyeva, P.V., Chastina, O.V., Petrova, M.M., Lareva, N.V., Garganeeva, N.P., Chumakova, G.A., Cherniaeva, M.S., Shnayder, N.A. New Genetic Biomarkers of the Overlap Syndrome Tension-Type Headache and Arterial Hypertension. Genes 2022; 13: 1823. DOI: 10.3390/genes13101823
9. Alyabyeva, P.V., Petrova, M.M., Dmitrenko, D.V., Garganeeva, N.P., Chumakova, G.A., Al-Zamil, M., Trefilova, V.V., Nasyrova, R.F., Shnayder, N.A. Association of Single-Nucleotide Polymorphisms Rs2779249 (chr17:26128581 C>A) and Rs rs2297518 (chr17: chr17:27769571 G>A) of the NOS2 Gene with Tension-Type Headache and Arterial Hypertension Overlap Syndrome in Eastern Siberia. Genes 2023; 14: 513. https://doi.org/10.3390/genes14020513
10. Alyabyeva, P.V., Reznichenko, P.A., Shnayder, N.A., Kaskaeva, D.S., Petrova, M.M. The role of the rs2297518 of NOS2 gene as a genetic biomarker of arterial hypertension and “arterial hypertension and tension-type headache” phenotype (the pilot study in East Siberia). Arterial Hypertension. 2022; 28(6): 699-709. (In Russ.). DOI: 10.18705/1607-419X-2022-28-6-699-709
11. Nasyrova, R.F., Moskaleva, P.V., Vaiman, E.E., Shnayder, N.A., Blatt, N.L., Rizvanov, A.A. Genetic factors of nitric oxide’s system in psychoneurologic disorders. Int. J. Mol. Sci. 2020; 21: 1604. DOI: 10.3390/ijms21051604
Review
For citations:
Alyabyeva P.V. The Personalized Algorithm of the “Tension-Type Headache and Arterial Hypertension” Phenotype Diagnosis. Personalized Psychiatry and Neurology. 2023;3(1):53-58. https://doi.org/10.52667/2712-9179-2023-3-1-53-58
Views:
521
Email this article 