ppanPersonalized Psychiatry and NeurologyPersonalized Psychiatry and Neurology2712-9179V. M. Bekhterev National Medical Research Centre for Psychiatry and Neurology of the Ministry of Health of the Russian Federation (Bekhterev NMRC PN)10.52667/2712-9179-2023-3-2-54-60ppan-85Research ArticleARTICLEClinical Features of Essential Tremor in the Two Ethnic GroupsGovorovaT. G.

Tatiana G. Govorova

677027, Yakutsk

PopovaT. E.

Tatiana E. Popova

677019, Yakutsk

Tel.: +7 (411) 2-31-93-94

tata2504@yandex.ruTappakhovA. A.

Aleksey A. Tappakhov

677027, Yakutsk

677019, Yakutsk

AndreevM. E.

Michil E. Andreev

677019, Yakutsk

M.K. Ammosov North-Eastern Federal University’s ClinicRussian FederationYakut Science Centre of Complex Medical ProblemsRussian FederationM.K. Ammosov North-Eastern Federal University’s Clinic; Yakut Science Centre of Complex Medical ProblemsRussian Federation202315112023325460Copyright © Govorova T.G., Popova T.E., Tappakhov A.A., Andreev M.E., 20232023Govorova T.G., Popova T.E., Tappakhov A.A., Andreev M.E.Govorova T.G., Popova T.E., Tappakhov A.A., Andreev M.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jppn.ru/jour/article/view/85

Objective: The aim of the study was to study the clinical features of essential tremor (ET) in residents of the Republic of Sakha (Yakutia) in various ethnic groups.Material and methods. The study involved 53 patients with an established diagnosis of essential tremor. All patients underwent a detailed neurological examination with a quantitative assessment of the severity and severity of tremor, as well as the degree of maladjustment and activity in everyday life using unified scales.Results and Discussions. It was revealed that the clinical variant of essential tremor-plus, associated with a more severe course and disability of patients. In the representatives of the Russian ethnic group, with the classic version of essential tremor, a combination of head tremor and hand tremor is observed, as well as a more rapid progression of disease symptoms. Representatives of the Yakut ethnic group in the clinical picture of essential tremor-plus are statistically significantly more likely to have a dystonic head position.Conclusion. Clinical variability of essential tremor with differences in the ethnic aspect in the rate of progression and in the frequency of the combination of action tremor with dystonic head position was demonstrated.

essential tremoressential tremor-plustrembling hyperkinesismotor symptomsReferencesLouis, E.D. Essential tremor: evolving clinicopathological concepts in an era of intensive post-mortem enquiry. Lancet Neurol. 2010; 9(6): 613–622. DOI: 10.1016/S1474-4422(10)70090-9Louis, E.D. Essential tremor: evolving clinicopathological concepts in an era of intensive post-mortem enquiry. Lancet Neurol. 2010; 9(6): 613–622. DOI: 10.1016/S1474-4422(10)70090-9Illarioshkin, S.N.; Ivanova-Smolenskaya, I.A. Drozhatel'nye giperkinezy: Rukovodstvo dlya vrachej. M: Atmosfera, 2011: 360 (in Russ.)Illarioshkin, S.N.; Ivanova-Smolenskaya, I.A. Drozhatel'nye giperkinezy: Rukovodstvo dlya vrachej. M: Atmosfera, 2011: 360 (in Russ.)Louis, E.D.; Broussolle, E.; Goetz, C.G.; Krack, P.; Kaufmann, P.; Mazzoni, P. Historical underpinnings of the term essential tremor in the late 19th century. Neurology. 2008; 71(11):856–859. DOI: 10.1212/01.wnl.0000325564.38165.d1Louis, E.D.; Broussolle, E.; Goetz, C.G.; Krack, P.; Kaufmann, P.; Mazzoni, P. Historical underpinnings of the term essential tremor in the late 19th century. Neurology. 2008; 71(11):856–859. DOI: 10.1212/01.wnl.0000325564.38165.d1Louis, E.D.; Faust, Ph.L. Essential tremor within the broader context of other forms of cerebellar degeneration faust Cerebellum. Cerebellum. 2020; 19(6): 879–96. doi: 10.1007/s12311-020-01160-4Louis, E.D.; Faust, Ph.L. Essential tremor within the broader context of other forms of cerebellar degeneration faust Cerebellum. Cerebellum. 2020; 19(6): 879–96. doi: 10.1007/s12311-020-01160-4Clark, L.N.; Louis ,E.D. Essential tremor. Handb Clin Neurol. 2018; 147: 229–239. doi: 10.1016/B978-0-444-63233-3.00015-4Clark, L.N.; Louis ,E.D. Essential tremor. Handb Clin Neurol. 2018; 147: 229–239. doi: 10.1016/B978-0-444-63233-3.00015-4Gerbasi, M.E.; Nambiar, Sh.; Reed, S.; Hennegan, K.; Hadker, N.; Eldar-Lissai, A.; Cosentino, S. Essential tremor patients experience significant burden beyond tremor: A systematic literature review. Front Neurol. 2022; 13: 891446. doi: 10.3389/fneur.2022.891446Gerbasi, M.E.; Nambiar, Sh.; Reed, S.; Hennegan, K.; Hadker, N.; Eldar-Lissai, A.; Cosentino, S. Essential tremor patients experience significant burden beyond tremor: A systematic literature review. Front Neurol. 2022; 13: 891446. doi: 10.3389/fneur.2022.891446Lombardi, W.J.; Woolston, D.J.; Roberts, J.W.; Gross, R.E. Cognitive deficits in patients with essential tremor. Neurology. 2001; 57(5):785–790. DOI: 10.1212/wnl.57.5.785Lombardi, W.J.; Woolston, D.J.; Roberts, J.W.; Gross, R.E. Cognitive deficits in patients with essential tremor. Neurology. 2001; 57(5):785–790. DOI: 10.1212/wnl.57.5.785Benito-León, J.; Louis, E.D.; Mitchell, A.J.; Bermejo-Pareja, F. Elderly-Onset Essential Tremor and Mild Cognitive Impairment: A Population-Based Study (NEDICES). J. Alzheimer’s Dis. 2011; 23(4):727–735. DOI: 10.3233/JAD-2011-101572Benito-León, J.; Louis, E.D.; Mitchell, A.J.; Bermejo-Pareja, F. Elderly-Onset Essential Tremor and Mild Cognitive Impairment: A Population-Based Study (NEDICES). J. Alzheimer’s Dis. 2011; 23(4):727–735. DOI: 10.3233/JAD-2011-101572Bermejo-Pareja, F. Essential tremor – a neurodegenerative disorder associated with cognitive defects? Nat Rev Neurol. 2011;7: 273–282. DOI: 10.1038/nrneurol.2011.44Bermejo-Pareja, F. Essential tremor – a neurodegenerative disorder associated with cognitive defects? Nat Rev Neurol. 2011;7: 273–282. DOI: 10.1038/nrneurol.2011.44Louis, E.D.; Benito-León, J.; Bermejo-Pareja, F. Self-reported depression and anti-depressant medication use in essential tremor: cross-sectional and prospective analyses in a population-based study. Eur. J. Neurol. 2007; 14(10):1138–1146. DOI: 10.1111/j.1468 1331.2007.01923.xLouis, E.D.; Benito-León, J.; Bermejo-Pareja, F. Self-reported depression and anti-depressant medication use in essential tremor: cross-sectional and prospective analyses in a population-based study. Eur. J. Neurol. 2007; 14(10):1138–1146. DOI: 10.1111/j.1468 1331.2007.01923.xBhatia, K.P.; Bain, P.; Bajaj, N.; Elble, R.J.; Hallett, M.; Louis, E.D.; Raethjen, J.; Stamelou, M.; Testa, C.M.; Deuschl, G. Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society. Mov. Disord. 2018; 33(1):75–87. DOI: 10.1002/mds.27121Bhatia, K.P.; Bain, P.; Bajaj, N.; Elble, R.J.; Hallett, M.; Louis, E.D.; Raethjen, J.; Stamelou, M.; Testa, C.M.; Deuschl, G. Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society. Mov. Disord. 2018; 33(1):75–87. DOI: 10.1002/mds.27121Louis, E.D. The primary type of tremor in essential tremor is kinetic rather than postural: cross-sectional observation of tremor phenomenology in 369 cases. Eur. J. Neurol. 2013; 20(4):725-727. DOI: 10.1111/j.1468-1331.2012.03855.xLouis, E.D. The primary type of tremor in essential tremor is kinetic rather than postural: cross-sectional observation of tremor phenomenology in 369 cases. Eur. J. Neurol. 2013; 20(4):725-727. DOI: 10.1111/j.1468-1331.2012.03855.xDeuschl, G.; Elble, R. Essential tremor–neurodegenerative or nondegenerative disease towards a working definition of ET. Mov. Disord. 2009; 24(14): 2033–2041. DOI: 10.1002/mds.22755Deuschl, G.; Elble, R. Essential tremor–neurodegenerative or nondegenerative disease towards a working definition of ET. Mov. Disord. 2009; 24(14): 2033–2041. DOI: 10.1002/mds.22755Louis, E.D. Twelve clinical pearls to help distinguish essential tremor from other tremors. Expert Rev. Neurother. 2014; 14(9):1057–1065. DOI: 10.1586/14737175.2014.936389Louis, E.D. Twelve clinical pearls to help distinguish essential tremor from other tremors. Expert Rev. Neurother. 2014; 14(9):1057–1065. DOI: 10.1586/14737175.2014.936389Fahn, S.; Tolosa, E.; Marin, C. Clinical rating scale for tremor. Park. Dis. Mov. Disord. Balt. MD Williams Wilkins. 1993; 271–280.Fahn, S.; Tolosa, E.; Marin, C. Clinical rating scale for tremor. Park. Dis. Mov. Disord. Balt. MD Williams Wilkins. 1993; 271–280.Stacy, M.A.; Elble, R.J.; Ondo, W.G.; Wu, S.; Hulihan, J.; TRS study group. Assessment of interrater and intrarater reliability of the Fahn-Tolosa-Marin Tre,mor Rating Scale in essential tremor. Mov. Disord. 2007; 22(6):833–838. DOI: 10.1002/mds.21412Stacy, M.A.; Elble, R.J.; Ondo, W.G.; Wu, S.; Hulihan, J.; TRS study group. Assessment of interrater and intrarater reliability of the Fahn-Tolosa-Marin Tre,mor Rating Scale in essential tremor. Mov. Disord. 2007; 22(6):833–838. DOI: 10.1002/mds.21412Sweet, R.D.; Blumberg, J.; Lee, J.E.; Dowell, F.H.Mc. Propranolol treatment of essential tremor. Neurology. 1974; 24(1): 64–64. DOI: 10.1212/wnl.24.1.64Sweet, R.D.; Blumberg, J.; Lee, J.E.; Dowell, F.H.Mc. Propranolol treatment of essential tremor. Neurology. 1974; 24(1): 64–64. DOI: 10.1212/wnl.24.1.64Bain, P.G.; Findley, L.J.; Atchison, P.; Behari, M.; Vidailhet, M.; Gresty, M.; Rothwell, J.C.; Thompson, P.D.; Marsden, C.D. Assessing tremor severity. J. Neurol. Neurosurg. Psychiatry.1993; 56(8): 868–873. DOI: 10.1136/jnnp.56.8.868Bain, P.G.; Findley, L.J.; Atchison, P.; Behari, M.; Vidailhet, M.; Gresty, M.; Rothwell, J.C.; Thompson, P.D.; Marsden, C.D. Assessing tremor severity. J. Neurol. Neurosurg. Psychiatry.1993; 56(8): 868–873. DOI: 10.1136/jnnp.56.8.868

The authors declare that there are no conflicts of interest present.