ppanPersonalized Psychiatry and NeurologyPersonalized Psychiatry and Neurology2712-9179V. M. Bekhterev National Medical Research Centre for Psychiatry and Neurology of the Ministry of Health of the Russian Federation (Bekhterev NMRC PN)10.52667/2712-9179-2023-3-1-66-78ppan-71Research ArticleCASE REPORTTranscranial Magnetic Stimulation for Catatonia: Cases SerieZakharovaN. V.

Natalia V. Zakharova

Moscow

pkb1@zdrav.mos.ruMamedovaG. S.

Galina S. Mamedova

Moscow

ShkurinovaM. A.

Maria A. Shkurinova

Moscow

KartashovS. I.

Sergey I. Kartashov

Moscow

ZaborinA.

Alexander Zaborin

Moscow

OrlovV. A.

Vyacheslav A. Orlov

Moscow

KholodnyY. I.

Yuriy I. Kholodny

Moscow

Mental-health Clinic No. 1 named after N.A. AlexeevRussian FederationNational Research Center Kurchatov InstituteRussian Federation202317052023316678Copyright © Zakharova N.V., Mamedova G.S., Shkurinova M.A., Kartashov S.I., Zaborin A., Orlov V.A., Kholodny Y.I., 20232023Zakharova N.V., Mamedova G.S., Shkurinova M.A., Kartashov S.I., Zaborin A., Orlov V.A., Kholodny Y.I.Zakharova N.V., Mamedova G.S., Shkurinova M.A., Kartashov S.I., Zaborin A., Orlov V.A., Kholodny Y.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jppn.ru/jour/article/view/71

The article presents the results of transcranial magnetic stimulation of dorsolateral prefrontal cortex (DLPFC) in four patients with catatonia. The uniqueness of these observations arises from three factors. First, rehabilitation neuromodulation of catatonia was used in a personalized course of exposure to magnetic pulses, considering the intensity of regional cerebral blood flow (rCBF) in the affected area. Secondly, the entire course of treatment was carried out on an outpatient basis. Thirdly, the content of Gamma-aminobutyric-acid (GABA) and glutamate in the cerebral cortex was additionally studied before and after the course of transcranial magnetic stimulation (TMS). All four patients were diagnosed with catatonia as part of schizophrenia spectrum disorders in three cases and in one case within the structure of recurrent depression phase. All patients took monotherapy with atypical antipsychotics as the main psychopharmacotherapy, were compliant and gave informed voluntary consent. The effectiveness of TMS was recorded in three cases. There were no adverse events or complications in all 20 sessions.

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The authors declare that there are no conflicts of interest present.