ppanPersonalized Psychiatry and NeurologyPersonalized Psychiatry and Neurology2712-9179V. M. Bekhterev National Medical Research Centre for Psychiatry and Neurology of the Ministry of Health of the Russian Federation (Bekhterev NMRC PN)10.52667/2712-9179-2022-2-1-67-72ppan-41Research ArticleARTICLEPCR-based Approach for Determining the Genetic Risk Factors of Antipsychotic-Induced Metabolic DisordersMironovK. O.

Konstantin O. Mironov

Moscow, 111123; Tel.: 8-495-788-00-02

mironov@pcr.ruGaponovaI. I.

Irina I. Gaponova

Moscow, 111123

KorchaginV. I.

Vitaly I. Korchagin

Moscow, 111123

EsmanA. S.

Anna S. Esman

Moscow, 111123

DunaevaE. A.

Elena A. Dunaeva

Moscow, 111123

ZhivotovaV. A.

Vera A. Zhivotova

Moscow, 111123

DobrodeevaV. S.

Vera S. Dobrodeeva

Saint-Petersburg, 192019

ShnayderN. A.

Natalia A. Shnayder

Saint-Petersburg, 192019; Krasnoyarsk, 660022

NeznanovN. G.

Nikolay G. Neznanov

Saint-Petersburg, 192019

 

NasyrovaR. F.

Regina F. Nasyrova

Saint-Petersburg, 192019

Central Research Institute of EpidemiologyRussian FederationInstitute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and NeurologyRussian FederationInstitute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology; Shared Core Facilities Molecular and Cell Technologies, V. F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation202215052022216772Copyright © Mironov K.O., Gaponova I.I., Korchagin V.I., Esman A.S., Dunaeva E.A., Zhivotova V.A., Dobrodeeva V.S., Shnayder N.A., Neznanov N.G., Nasyrova R.F., 20222022Mironov K.O., Gaponova I.I., Korchagin V.I., Esman A.S., Dunaeva E.A., Zhivotova V.A., Dobrodeeva V.S., Shnayder N.A., Neznanov N.G., Nasyrova R.F.Mironov K.O., Gaponova I.I., Korchagin V.I., Esman A.S., Dunaeva E.A., Zhivotova V.A., Dobrodeeva V.S., Shnayder N.A., Neznanov N.G., Nasyrova R.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jppn.ru/jour/article/view/41

The antipsychotic-induced metabolic disorders (AIMD) are common side effects during the treatment of schizophrenia. Single nucleotide polymorphisms in the genes associated with AIMD, in particular in the leptin and neuropeptide Y genes were explored. The aim of this study was to develop a real-time PCR technique for SNP allele discrimination and allele frequency estimation in the Russian population. A total of 9 real-time PCR tests for rs7799039, rs1137101, rs8179183, rs16147, rs6837793, rs11100494, rs1414334, rs3813929 and rs518147 SNPs were developed and examined using 106 DNA samples. The revealed allele frequencies did not show any statistically significant differences with ones for the Caucasian population from Ensembl data base. Thus, our results are in accordance with the allele frequencies for the studied populations and allow using published data on the risk alleles for the development of new diagnostics PCR kits for the complex diagnostics of AIMD.

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The authors declare that there are no conflicts of interest present.