ppanPersonalized Psychiatry and NeurologyPersonalized Psychiatry and Neurology2712-9179V. M. Bekhterev National Medical Research Centre for Psychiatry and Neurology of the Ministry of Health of the Russian Federation (Bekhterev NMRC PN)10.52667/2712-9179-2021-1-2-46-62ppan-23Research ArticleREVIEWPerspectives of personalized approach to prevention and treatment of anticonvulsant-induced osteoporosis via action on vitamin D exchange and VDR expressionDontsevaE. A.

Eugenia А. Dontseva

Novosibirsk

shapo_jain@mail.ruTrefilovaV. V.

Vera V. Trefilova

St. Petersburg

vera.v.trefilova@yandex.comPopovaT. E.

Tatiana E. Popova

Yakutsk

tata2504@yandex.ruPetrovaM. M.

Marina M. Petrova

Krasnoyarsk

stk99@yandex.ruAl-ZamilM.

Mustafa Al-Zamil

Moscow

alzamil@mail.ruNovosibirsk State Medical UniversityRussian FederationThe Hospital for War VeteransRussian FederationTheYakutsk Scientific Center for Complex Medical ProblemsRussian FederationV. F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityRussian FederationPeoples' Friendship University of RussiaRussian Federation202114112021124662Copyright © Dontseva E.A., Trefilova V.V., Popova T.E., Petrova M.M., Al-Zamil M., 20212021Dontseva E.A., Trefilova V.V., Popova T.E., Petrova M.M., Al-Zamil M.Dontseva E.A., Trefilova V.V., Popova T.E., Petrova M.M., Al-Zamil M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jppn.ru/jour/article/view/23

Anticonvulsant-induced osteoporosis (AIO) and associated pain syndromes and patient disabilities are an important interdisciplinary medical problem generated by various molecular, genetic and pathophysiological mechanisms. AIO are the most important pathological processes associated with chronic pain in adults with epilepsy. Standard approaches to their prevention and treatment do not always solve the problem of the progression of the pathological process and chronicity of AIO. This is the reason for the search for new personalized strategies for the prevention and treatment of AIO. Vitamin D metabolism, expression and specificity of vitamin D receptors (VDRs) may play a key role in the development of AIO and chronic back pain in patients with epilepsy. The aim of the study was to review publications on changes in the vitamin D system in patients with AIO. We searched for articles published in e-Library, PubMed, Oxford Press, Clinical Case, Springer, Elsevier, and Google Scholar. The search was carried out by key-words and their combinations. The role of vitamin D and VDR in the development of AIO and the chronicity of back pain has been demonstrated mainly in animal models and humans. Associative genetic studies have shown that single nucleotide variants (SNVs) of the VDR gene encoding VDR may be associated with the development of osteoporosis of the spine (including those associated with the intake of an anticonvulsants). The prospects for the use of vitamin D preparations for modulating the effect of anticonvulsants used to treat epilepsy are discussed. Genetic association studies of VDR gene SNVs are important for understanding the genetic predictors of AIO and chronic back pain in patients with epilepsy, as well as for developing new personalized pharmacotherapy strategies.

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The authors declare that there are no conflicts of interest present.