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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">ppan</journal-id><journal-title-group><journal-title xml:lang="en">Personalized Psychiatry and Neurology</journal-title><trans-title-group xml:lang="ru"><trans-title>Personalized Psychiatry and Neurology</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2712-9179</issn><publisher><publisher-name>V. M. Bekhterev National Medical Research Centre for Psychiatry and Neurology of the Ministry of Health of the Russian Federation (Bekhterev NMRC PN)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52667/2712-9179-2024-4-3-24-36</article-id><article-id custom-type="elpub" pub-id-type="custom">ppan-109</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Animal Models of Vascular Cognitive Disorder after Myocardial Infarction: Scoping Review</article-title><trans-title-group xml:lang="ru"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Petrov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="en"><p>Artem V. Petrov</p><p>660022 Krasnoyarsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Shnayder</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="en"><p>Natalia A. Shnayder</p><p>660022 Krasnoyarsk</p><p>192019 Saint Petersburg</p></bio><email xlink:type="simple">naschnaider@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Petrova</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="en"><p>Marina M. Petrova</p><p>660022 Krasnoyarsk</p></bio><email xlink:type="simple">stk99@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Evsyukov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="en"><p>Aleksandr A. Evsyukov</p><p>660022 Krasnoyarsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Kaskaeva</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="en"><p> Darya S. Kaskaeva</p><p>660022 Krasnoyarsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Dmitrenko</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="en"><p>Diana V. Dmitrenko</p><p>660022 Krasnoyarsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Malinovskaya</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="en"><p> Natalia A. Malinovskaya </p><p>660022 Krasnoyarsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="en">V.F. Voino-Yasenetsky Krasnoyarsk State Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="en">V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>18</day><month>09</month><year>2024</year></pub-date><volume>4</volume><issue>3</issue><fpage>24</fpage><lpage>36</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Petrov A.V., Shnayder N.A., Petrova M.M., Evsyukov A.A., Kaskaeva D.S., Dmitrenko D.V., Malinovskaya N.A., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Petrov A.V., Shnayder N.A., Petrova M.M., Evsyukov A.A., Kaskaeva D.S., Dmitrenko D.V., Malinovskaya N.A.</copyright-holder><copyright-holder xml:lang="en">Petrov A.V., Shnayder N.A., Petrova M.M., Evsyukov A.A., Kaskaeva D.S., Dmitrenko D.V., Malinovskaya N.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jppn.ru/jour/article/view/109">https://www.jppn.ru/jour/article/view/109</self-uri><abstract><p>Vascular cognitive disorders (VCD) are one of the most common forms of non-psychotic mental disorders with a variable phenotype and rate of progression, transformation into vascular dementia. VCD is characterized by development against the background of existing cardiovascular diseases (CVD), which explains the importance of an interdisciplinary approach to their diagnosis and treatment. The study of new mechanisms of development of VCD can help in finding the key to the development of innovative diagnostic methods and personalized treatment approaches. The purpose of this thematic review is to search, generalize and systematize domestic and foreign research in the field of fundamental neurology using methods of modeling VCD in experimental animals. The authors conducted a search for publications in the databases PubMed, Springer, Web of Science, Clinical Keys, Scopus, Oxford Press, Cochrane, e-Library using keywords and their combinations. The publications for 2005-2024 were analyzed, including original studies of VCD and vascular dementia.</p></abstract><kwd-group xml:lang="en"><kwd>fundamental neurology</kwd><kwd>cognitive functions</kwd><kwd>vascular cognitive disorders</kwd><kwd>experiment</kwd><kwd>animal  model</kwd><kwd>disease modeling</kwd></kwd-group><funding-group xml:lang="en"><funding-statement>Voino-Yasenetsky Krasnoyarsk State Medical University National of the Ministry of Health of Russia 2022 - 2025 (“Development of a personalized algorithm for diagnosing vascular moderate cognitive dysfunction against the background of acute myocardial infarction based on new genetic  and biochemical biomarkers”, No. 123022800057-6).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Verdelho, A.; Wardlaw, J.; Pavlovic, A.; Pantoni, L.; Godefroy, O.; Duering, M.; Charidimou, A.; Chabriat, H.; Biessels, G.J. Cognitive impairment in patients with cerebrovascular disease: A white paper from the links between stroke ESO Dementia Committee. Eur Stroke J. 2021, 6(1): 5-17. doi: 10.1177/23969873211000258</mixed-citation><mixed-citation xml:lang="en">Verdelho, A.; Wardlaw, J.; Pavlovic, A.; Pantoni, L.; Godefroy, O.; Duering, M.; Charidimou, A.; Chabriat, H.; Biessels, G.J. Cognitive impairment in patients with cerebrovascular disease: A white paper from the links between stroke ESO Dementia Committee. Eur Stroke J. 2021, 6(1): 5-17. doi: 10.1177/23969873211000258</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kalaria, R.N. Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for alzheimer's disease. Acta Neuropathol. 2016, 131: 659–685. doi: 10.1007/s00401-016-1571-z</mixed-citation><mixed-citation xml:lang="en">Kalaria, R.N. Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for alzheimer's disease. Acta Neuropathol. 2016, 131: 659–685. doi: 10.1007/s00401-016-1571-z</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Gavrilova, E.S.; Yashina, L.M. Evaluation of cardiovascular risk factors and educational technologies of the correction in youth population. Siberian Medical Review. 2017, (2): 48-55. doi: 10.20333/2500136-2017-2-48-55. (In Russian)</mixed-citation><mixed-citation xml:lang="en">Gavrilova, E.S.; Yashina, L.M. Evaluation of cardiovascular risk factors and educational technologies of the correction in youth population. Siberian Medical Review. 2017, (2): 48-55. doi: 10.20333/2500136-2017-2-48-55. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Balasubramanian, P.; DelFavero, J.; Ungvari, A.; Papp, M.; Tarantini, A.; Price, N.; de Cabo, R.; Tarantini, S. Time-restricted feeding (TRF) for prevention of age-related vascular cognitive impairment and dementia. Ageing Res Rev. 2020, 64:101189. doi: 10.1016/j.arr.2020.101189</mixed-citation><mixed-citation xml:lang="en">Balasubramanian, P.; DelFavero, J.; Ungvari, A.; Papp, M.; Tarantini, A.; Price, N.; de Cabo, R.; Tarantini, S. Time-restricted feeding (TRF) for prevention of age-related vascular cognitive impairment and dementia. Ageing Res Rev. 2020, 64:101189. doi: 10.1016/j.arr.2020.101189</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Wolters, F.J.; Ikram, M.A. Epidemiology of vascular dementia. Arterioscler Thromb Vasc Biol. 2019, 39:1542–1549. doi: 10.1161/ATVBAHA.119.311908</mixed-citation><mixed-citation xml:lang="en">Wolters, F.J.; Ikram, M.A. Epidemiology of vascular dementia. Arterioscler Thromb Vasc Biol. 2019, 39:1542–1549. doi: 10.1161/ATVBAHA.119.311908</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ministry of Health of the Russian Federation. Clinical recommendations. Cognitive disorders in the elderly and senile. https://cr.minzdrav.gov.ru/schema/617_1 (In Russian)</mixed-citation><mixed-citation xml:lang="en">Ministry of Health of the Russian Federation. Clinical recommendations. Cognitive disorders in the elderly and senile. https://cr.minzdrav.gov.ru/schema/617_1 (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Iadecola, C.; Duering, M.; Hachinski, V.; Joutel, A.; Pendlebury, S.T.; Schneider, J.A., Dichgans M. Vascular cognitive impairment and dementia: JACC scientific expert panel. J Am Coll Cardiol. 2019, 73(25):3326-3344. doi: 10.1016/j.jacc.2019.04.034</mixed-citation><mixed-citation xml:lang="en">Iadecola, C.; Duering, M.; Hachinski, V.; Joutel, A.; Pendlebury, S.T.; Schneider, J.A., Dichgans M. Vascular cognitive impairment and dementia: JACC scientific expert panel. J Am Coll Cardiol. 2019, 73(25):3326-3344. doi: 10.1016/j.jacc.2019.04.034</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Parfenov, V.A. Diagnosis and treatment of vascular cognitive impairment, the use of citicoline: A review. Consilium Medicum. 2024, 26(2):112-116. doi: 10.26442/20751753.2024.2.202719. (In Russian)</mixed-citation><mixed-citation xml:lang="en">Parfenov, V.A. Diagnosis and treatment of vascular cognitive impairment, the use of citicoline: A review. Consilium Medicum. 2024, 26(2):112-116. doi: 10.26442/20751753.2024.2.202719. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Chang Wong, E.; Chang Chui, H. Vascular cognitive impairment and dementia. Continuum (Minneap Minn). 2022, 28(3): 750-780. doi:10.1212/CON.0000000000001124</mixed-citation><mixed-citation xml:lang="en">Chang Wong, E.; Chang Chui, H. Vascular cognitive impairment and dementia. Continuum (Minneap Minn). 2022, 28(3): 750-780. doi:10.1212/CON.0000000000001124</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Rundek, T.; Tolea, M.; Ariko, T.; Fagerli, E.A.; Camargo, C.J. Vascular cognitive impairment (VCI). Neurotherapeutics. 2022, 19(1):68-88. doi:10.1007/s13311-021-01170-y]</mixed-citation><mixed-citation xml:lang="en">Rundek, T.; Tolea, M.; Ariko, T.; Fagerli, E.A.; Camargo, C.J. Vascular cognitive impairment (VCI). Neurotherapeutics. 2022, 19(1):68-88. doi:10.1007/s13311-021-01170-y]</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Yang, Y.; Kimura-Ohba, S.; Thompson, J.; Rosenberg, G.A. Rodent models of vascular cognitive impairment. Transl Stroke Res. 2016, 7(5):407-414. doi:10.1007/s12975-016-0486-2</mixed-citation><mixed-citation xml:lang="en">Yang, Y.; Kimura-Ohba, S.; Thompson, J.; Rosenberg, G.A. Rodent models of vascular cognitive impairment. Transl Stroke Res. 2016, 7(5):407-414. doi:10.1007/s12975-016-0486-2</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Weng, Z.; Cao, C.; Stepicheva, N.A.; Chen, F.; Foley, L.M.; Cao, S.; Bhuiyan, M.I.H.; Wang, Q.; Wang, Y.; Hitchens, T. K.; Sun, D.; Cao, G.A. Novel needle mouse model of vascular cognitive impairment and dementia. The Journal of Neuroscience 2023, 43(44):7351–7360. doi: 10.1523/JNEUROSCI.0282-23.2023</mixed-citation><mixed-citation xml:lang="en">Weng, Z.; Cao, C.; Stepicheva, N.A.; Chen, F.; Foley, L.M.; Cao, S.; Bhuiyan, M.I.H.; Wang, Q.; Wang, Y.; Hitchens, T. K.; Sun, D.; Cao, G.A. Novel needle mouse model of vascular cognitive impairment and dementia. The Journal of Neuroscience 2023, 43(44):7351–7360. doi: 10.1523/JNEUROSCI.0282-23.2023</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Dorofeikova, M.V.; Petrova, N.N.; Egorov, A.Yu. Animal models of cognitive impairment in neurodegenerative and organic disorders. Russian Journal of Physiology 2020, 106(2):157–175. doi: 10.31857/S086981392002003X</mixed-citation><mixed-citation xml:lang="en">Dorofeikova, M.V.; Petrova, N.N.; Egorov, A.Yu. Animal models of cognitive impairment in neurodegenerative and organic disorders. Russian Journal of Physiology 2020, 106(2):157–175. doi: 10.31857/S086981392002003X</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Stewart, A.M.; Kalueff, A.V. Developing better and more valid animal models of brain disorders. Behav. Brain Res. 2015, 276:28-31. doi: 10.1016/j.bbr.2013.12.024</mixed-citation><mixed-citation xml:lang="en">Stewart, A.M.; Kalueff, A.V. Developing better and more valid animal models of brain disorders. Behav. Brain Res. 2015, 276:28-31. doi: 10.1016/j.bbr.2013.12.024</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Thong, E.H.E.; Quek, E.J.W.; Loo, J.H.; Yun, C.Y.; Teo, Y.N.; Teo, Y.H.; Leow, A.S.T.; Li, T.Y.W.; Sharma, V.K.; Tan, B.Y.Q.; Yeo, L.L.L.; Chong, Y.F.; Chan, M.Y.; Sia, C.H. Acute myocardial infarction and risk of cognitive impairment and dementia: A review. Biology (Basel) 2023, 12(8):1154. doi: 10.3390/biology12081154</mixed-citation><mixed-citation xml:lang="en">Thong, E.H.E.; Quek, E.J.W.; Loo, J.H.; Yun, C.Y.; Teo, Y.N.; Teo, Y.H.; Leow, A.S.T.; Li, T.Y.W.; Sharma, V.K.; Tan, B.Y.Q.; Yeo, L.L.L.; Chong, Y.F.; Chan, M.Y.; Sia, C.H. Acute myocardial infarction and risk of cognitive impairment and dementia: A review. Biology (Basel) 2023, 12(8):1154. doi: 10.3390/biology12081154</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Leto, L.; Feola, M. Cognitive impairment in heart failure patients. J. Geriatr. Cardiol. 2014, 11:316–328. doi: 10.11909/j.issn.1671-5411.2014.04.007</mixed-citation><mixed-citation xml:lang="en">Leto, L.; Feola, M. Cognitive impairment in heart failure patients. J. Geriatr. Cardiol. 2014, 11:316–328. doi: 10.11909/j.issn.1671-5411.2014.04.007</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes, J.M.; Barnes, N.M.; Costall, B.; Horovitz, Z.P.; Ironside, J.W.; Naylor, R.J.; Williams, T.J. Angiotensin II inhibits cortical cholinergic function: Implications for cognition. J. Cardiovasc. Pharmacol. 1990, 16:234–238. doi: 10.1097/00005344-199008000-00009</mixed-citation><mixed-citation xml:lang="en">Barnes, J.M.; Barnes, N.M.; Costall, B.; Horovitz, Z.P.; Ironside, J.W.; Naylor, R.J.; Williams, T.J. Angiotensin II inhibits cortical cholinergic function: Implications for cognition. J. Cardiovasc. Pharmacol. 1990, 16:234–238. doi: 10.1097/00005344-199008000-00009</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Savaskan, E.; Hock, C.; Olivieri, G.; Bruttel, S.; Rosenberg, C.; Hulette, C.; Müller-Spahn, F. Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer’s dementia. Neurobiol. Aging. 2001, 22:541–546. doi: 10.1016/S0197-4580(00)00259-1</mixed-citation><mixed-citation xml:lang="en">Savaskan, E.; Hock, C.; Olivieri, G.; Bruttel, S.; Rosenberg, C.; Hulette, C.; Müller-Spahn, F. Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer’s dementia. Neurobiol. Aging. 2001, 22:541–546. doi: 10.1016/S0197-4580(00)00259-1</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Tooze, J.A.; Gaussoin, S.A.; Resnick, S.M.; Fischbein, N.J.; Robinson, J.G.; Bryan, R.N.; An, Y.; Espeland, M.A. A uniform approach to modeling risk factor relationships for ischemic lesion prevalence and extent: The Women’s Health Initiative magnetic resonance imaging study. Neuroepidemiology 2010, 34:55–62. doi: 10.1159/000260071</mixed-citation><mixed-citation xml:lang="en">Tooze, J.A.; Gaussoin, S.A.; Resnick, S.M.; Fischbein, N.J.; Robinson, J.G.; Bryan, R.N.; An, Y.; Espeland, M.A. A uniform approach to modeling risk factor relationships for ischemic lesion prevalence and extent: The Women’s Health Initiative magnetic resonance imaging study. Neuroepidemiology 2010, 34:55–62. doi: 10.1159/000260071</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kuller, L.H.; Margolis, K.L.; Gaussoin, S.A.; Bryan, N.R.; Kerwin, D.; Limacher, M.; Wassertheil-Smoller, S.; Williamson, J.; Robinson, J.G.; Group, W.H.I.M.S.R. Relationship of hypertension, blood pressure, and blood pressure control with white matter abnormalities in the Women’s Health Initiative Memory Study (WHIMS)—MRI trial. J. Clin. Hypertens. 2010, 12: 203–212. doi: 10.1111/j.1751-7176.2009.00234.x</mixed-citation><mixed-citation xml:lang="en">Kuller, L.H.; Margolis, K.L.; Gaussoin, S.A.; Bryan, N.R.; Kerwin, D.; Limacher, M.; Wassertheil-Smoller, S.; Williamson, J.; Robinson, J.G.; Group, W.H.I.M.S.R. Relationship of hypertension, blood pressure, and blood pressure control with white matter abnormalities in the Women’s Health Initiative Memory Study (WHIMS)—MRI trial. J. Clin. Hypertens. 2010, 12: 203–212. doi: 10.1111/j.1751-7176.2009.00234.x</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Iadecola, C. The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathol. 2010, 120:287–296. doi: 10.1007/s00401-010-0718-6</mixed-citation><mixed-citation xml:lang="en">Iadecola, C. The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathol. 2010, 120:287–296. doi: 10.1007/s00401-010-0718-6</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Lecrux, C.; Hamel, E. The neurovascular unit in brain function and disease. Acta Physiol. 2011, 203:47–59. doi: 10.1111/j.1748-1716.2011.02256.x</mixed-citation><mixed-citation xml:lang="en">Lecrux, C.; Hamel, E. The neurovascular unit in brain function and disease. Acta Physiol. 2011, 203:47–59. doi: 10.1111/j.1748-1716.2011.02256.x</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Zlokovic, B.V. Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders. Nat. Rev. Neurosci. 2011, 12:723–738. doi: 10.1038/nrn3114</mixed-citation><mixed-citation xml:lang="en">Zlokovic, B.V. Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders. Nat. Rev. Neurosci. 2011, 12:723–738. doi: 10.1038/nrn3114</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Tan, Z.S.; Beiser, A.S.; Vasan, R.S.; Roubenoff, R.; Dinarello, C.A.; Harris, T.B.; Benjamin, E.J.; Au, R.; Kiel, D.P.; Wolf, P.A. Inflammatory markers and the risk of Alzheimer disease: The Framingham Study. Neurology 2007, 68:1902–1908. doi: 10.1212/01.wnl.0000263217.36439.da</mixed-citation><mixed-citation xml:lang="en">Tan, Z.S.; Beiser, A.S.; Vasan, R.S.; Roubenoff, R.; Dinarello, C.A.; Harris, T.B.; Benjamin, E.J.; Au, R.; Kiel, D.P.; Wolf, P.A. Inflammatory markers and the risk of Alzheimer disease: The Framingham Study. Neurology 2007, 68:1902–1908. doi: 10.1212/01.wnl.0000263217.36439.da</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Tan, Z.S.; Beiser, A.S.; Fox, C.S.; Au, R.; Himali, J.J.; Debette, S.; DeCarli, C.; Vasan, R.S.; Wolf, P.A.; Seshadri, S. Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: The Framingham Offspring Study. Diabetes Care 2011, 34:1766–1770. doi: 10.2337/dc11-0308</mixed-citation><mixed-citation xml:lang="en">Tan, Z.S.; Beiser, A.S.; Fox, C.S.; Au, R.; Himali, J.J.; Debette, S.; DeCarli, C.; Vasan, R.S.; Wolf, P.A.; Seshadri, S. Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: The Framingham Offspring Study. Diabetes Care 2011, 34:1766–1770. doi: 10.2337/dc11-0308</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Sundbøll, J.; Horváth-Puhó, E.; Adelborg, K.; Schmidt, M.; Pedersen, L.; Bøtker, H.E.; Henderson, V.W.; Sørensen, H.T. Higher Risk of vascular dementia in myocardial infarction survivors. Circulation 2018, 137:567–577. doi: 10.1161/CIRCULATIONAHA.117.029127</mixed-citation><mixed-citation xml:lang="en">Sundbøll, J.; Horváth-Puhó, E.; Adelborg, K.; Schmidt, M.; Pedersen, L.; Bøtker, H.E.; Henderson, V.W.; Sørensen, H.T. Higher Risk of vascular dementia in myocardial infarction survivors. Circulation 2018, 137:567–577. doi: 10.1161/CIRCULATIONAHA.117.029127</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Alosco, M.L.; Hayes, S.M. Structural brain alterations in heart failure: A review of the literature and implications for risk of Alzheimer’s disease. Heart Fail. Rev. 2015, 20:561–571. doi: 10.1007/s10741-015-9488-5</mixed-citation><mixed-citation xml:lang="en">Alosco, M.L.; Hayes, S.M. Structural brain alterations in heart failure: A review of the literature and implications for risk of Alzheimer’s disease. Heart Fail. Rev. 2015, 20:561–571. doi: 10.1007/s10741-015-9488-5</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Alves, T.C.T.F.; Rays, J.; Fráguas, R.J.; Wajngarten, M.; Meneghetti, J.C.; Prando, S.; Busatto, G.F. Localized cerebral blood flow reductions in patients with heart failure: A study using 99mTc-HMPAO SPECT. J. Neuroimaging Off. J. Am. Soc. Neuroimaging. 2005, 15:150–156. doi: 10.1177/1051228404272880</mixed-citation><mixed-citation xml:lang="en">Alves, T.C.T.F.; Rays, J.; Fráguas, R.J.; Wajngarten, M.; Meneghetti, J.C.; Prando, S.; Busatto, G.F. Localized cerebral blood flow reductions in patients with heart failure: A study using 99mTc-HMPAO SPECT. J. Neuroimaging Off. J. Am. Soc. Neuroimaging. 2005, 15:150–156. doi: 10.1177/1051228404272880</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Almeida, J.R.C.; Alves, T.C.T.F.; Wajngarten, M.; Rays, J.; Castro, C.C.; Cordeiro, Q.; Telles, R.M.S.; Fraguas, R.J.; Busatto, G.F. Late-life depression, heart failure and frontal white matter hyperintensity: A structural magnetic resonance imaging study. Braz. J. Med. Biol. Res. 2005, 38:431–436. doi: 10.1590/S0100-879X2005000300014</mixed-citation><mixed-citation xml:lang="en">Almeida, J.R.C.; Alves, T.C.T.F.; Wajngarten, M.; Rays, J.; Castro, C.C.; Cordeiro, Q.; Telles, R.M.S.; Fraguas, R.J.; Busatto, G.F. Late-life depression, heart failure and frontal white matter hyperintensity: A structural magnetic resonance imaging study. Braz. J. Med. Biol. Res. 2005, 38:431–436. doi: 10.1590/S0100-879X2005000300014</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Stegmann, T.; Chu, M.L.; Witte, V.A.; Villringer, A.; Kumral, D.; Riedel-Heller, S.G.; Roehr, S.; Hagendorff, A.; Laufs, U.; Loeffler, M. Heart failure is independently associated with white matter lesions: Insights from the population-based LIFEAdult Study. ESC Heart Fail. 2021, 8:697–704. doi: 10.1002/ehf2.13166</mixed-citation><mixed-citation xml:lang="en">Stegmann, T.; Chu, M.L.; Witte, V.A.; Villringer, A.; Kumral, D.; Riedel-Heller, S.G.; Roehr, S.; Hagendorff, A.; Laufs, U.; Loeffler, M. Heart failure is independently associated with white matter lesions: Insights from the population-based LIFEAdult Study. ESC Heart Fail. 2021, 8:697–704. doi: 10.1002/ehf2.13166</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Ikram, M.A.; van Oijen, M.; de Jong, F.J.; Kors, J.A., Koudstaal, P.J.; Hofman, A.; Witteman, J.C.M.; Breteler, M.M.B. Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease. Stroke 2008, 39:1421–1426. doi: 10.1161/STROKEAHA.107.501106</mixed-citation><mixed-citation xml:lang="en">Ikram, M.A.; van Oijen, M.; de Jong, F.J.; Kors, J.A., Koudstaal, P.J.; Hofman, A.; Witteman, J.C.M.; Breteler, M.M.B. Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease. Stroke 2008, 39:1421–1426. doi: 10.1161/STROKEAHA.107.501106</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Thackeray, J.T.; Hupe, H.C.; Wang, Y.; Bankstahl, J.P.; Berding, G.; Ross, T.L.; Bauersachs, J.; Wollert, K.C.; Bengel, F.M. Myocardial Inflammation Predicts Remodeling and Neuroinflammation After Myocardial Infarction. J. Am. Coll. Cardiol. 2018, 71:263–275. doi: 10.1016/j.jacc.2017.11.024</mixed-citation><mixed-citation xml:lang="en">Thackeray, J.T.; Hupe, H.C.; Wang, Y.; Bankstahl, J.P.; Berding, G.; Ross, T.L.; Bauersachs, J.; Wollert, K.C.; Bengel, F.M. Myocardial Inflammation Predicts Remodeling and Neuroinflammation After Myocardial Infarction. J. Am. Coll. Cardiol. 2018, 71:263–275. doi: 10.1016/j.jacc.2017.11.024</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Goh, F.Q.; Kong, W.K.F.; Wong, R.C.C.; Chong, Y.F.; Chew, N.W.S.; Yeo, T.-C.; Sharma, V.K.; Poh, K.K.; Sia, C.-H. Cognitive Impairment in Heart Failure-A Review. Biology 2022, 11:179. doi: 10.3390/biology11020179</mixed-citation><mixed-citation xml:lang="en">Goh, F.Q.; Kong, W.K.F.; Wong, R.C.C.; Chong, Y.F.; Chew, N.W.S.; Yeo, T.-C.; Sharma, V.K.; Poh, K.K.; Sia, C.-H. Cognitive Impairment in Heart Failure-A Review. Biology 2022, 11:179. doi: 10.3390/biology11020179</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Georgiadis, D.; Sievert, M.; Cencetti, S.; Uhlmann, F.; Krivokuca, M.; Zierz, S.; Werdan, K. Cerebrovascular reactivity is impaired in patients with cardiac failure. Eur. Heart J. 2000, 21:407–413. doi: 10.1053/euhj.1999.1742</mixed-citation><mixed-citation xml:lang="en">Georgiadis, D.; Sievert, M.; Cencetti, S.; Uhlmann, F.; Krivokuca, M.; Zierz, S.; Werdan, K. Cerebrovascular reactivity is impaired in patients with cardiac failure. Eur. Heart J. 2000, 21:407–413. doi: 10.1053/euhj.1999.1742</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Gruhn, N.; Larsen, F.S.; Boesgaard, S.; Knudsen, G.M.; Mortensen, S.A.; Thomsen, G.; Aldershvile, J. Cerebral blood flow in patients with chronic heart failure before and after heart transplantation. Stroke 2001, 32:2530–2533. doi: 10.1161/hs1101.098360</mixed-citation><mixed-citation xml:lang="en">Gruhn, N.; Larsen, F.S.; Boesgaard, S.; Knudsen, G.M.; Mortensen, S.A.; Thomsen, G.; Aldershvile, J. Cerebral blood flow in patients with chronic heart failure before and after heart transplantation. Stroke 2001, 32:2530–2533. doi: 10.1161/hs1101.098360</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">De Jong, G.I.; Farkas, E.; Stienstra, C.M.; Plass, J.R.; Keijser, J.N.; de la Torre, J.C.; Luiten, P.G. Cerebral hypoperfusion yields capillary damage in the hippocampal CA1 area that correlates with spatial memory impairment. Neuroscience 1999, 91:203– 210. doi: 10.1016/S0306-4522(98)00659-9</mixed-citation><mixed-citation xml:lang="en">De Jong, G.I.; Farkas, E.; Stienstra, C.M.; Plass, J.R.; Keijser, J.N.; de la Torre, J.C.; Luiten, P.G. Cerebral hypoperfusion yields capillary damage in the hippocampal CA1 area that correlates with spatial memory impairment. Neuroscience 1999, 91:203– 210. doi: 10.1016/S0306-4522(98)00659-9</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Kure, C.E.; Rosenfeldt, F.L.; Scholey, A.B.; Pipingas, A.; Kaye, D.M.; Bergin, P.J.; Croft, K.D.; Wesnes, K.A.; Myers, S.P.; Stough, C. Relationships among cognitive function and cerebral blood flow, oxidative stress, and inflammation in older heart failure patients. J. Card. Fail. 2016, 22:548–559. doi: 10.1016/j.cardfail.2016.03.006</mixed-citation><mixed-citation xml:lang="en">Kure, C.E.; Rosenfeldt, F.L.; Scholey, A.B.; Pipingas, A.; Kaye, D.M.; Bergin, P.J.; Croft, K.D.; Wesnes, K.A.; Myers, S.P.; Stough, C. Relationships among cognitive function and cerebral blood flow, oxidative stress, and inflammation in older heart failure patients. J. Card. Fail. 2016, 22:548–559. doi: 10.1016/j.cardfail.2016.03.006</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Yang, T.; Lu, Z.; Wang, L.; Zhao, Y.; Nie, B.; Xu, Q.; Han, X.; Li, T.; Zhao, J.; Cheng, W.; Wang, B.; Wu, A.; Zhu, H.; Meng, W.; Shang, H.; Zhao, M. Dynamic changes in brain glucose metabolism and neuronal structure in rats with heart failure. Neuroscience 2020, 424:34–44. doi: 10.1016/j.neuroscience.2019.10.008</mixed-citation><mixed-citation xml:lang="en">Yang, T.; Lu, Z.; Wang, L.; Zhao, Y.; Nie, B.; Xu, Q.; Han, X.; Li, T.; Zhao, J.; Cheng, W.; Wang, B.; Wu, A.; Zhu, H.; Meng, W.; Shang, H.; Zhao, M. Dynamic changes in brain glucose metabolism and neuronal structure in rats with heart failure. Neuroscience 2020, 424:34–44. doi: 10.1016/j.neuroscience.2019.10.008</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Meissner, A.; Visanji, N.P.; Momen, M.A.; Feng, R.; Francis, B.M.; Bolz, S.; Hazrati, L. Tumor necrosis factor-α underlies loss of cortical dendritic spine density in a mouse model of congestive heart failure. J. Am. Heart Assoc. 2015, 4:e001920. doi: 10.1161/JAHA.115.001920</mixed-citation><mixed-citation xml:lang="en">Meissner, A.; Visanji, N.P.; Momen, M.A.; Feng, R.; Francis, B.M.; Bolz, S.; Hazrati, L. Tumor necrosis factor-α underlies loss of cortical dendritic spine density in a mouse model of congestive heart failure. J. Am. Heart Assoc. 2015, 4:e001920. doi: 10.1161/JAHA.115.001920</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Sudduth, T.L.; Powell, D.K.; Smith, C.D.; Greenstein, A.; Wilcock, D.M. Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation. J. Cereb. Blood. Flow. Metab. 2013, 33(5): 708–715. doi: 10.1038/jcbfm.2013.1</mixed-citation><mixed-citation xml:lang="en">Sudduth, T.L.; Powell, D.K.; Smith, C.D.; Greenstein, A.; Wilcock, D.M. Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation. J. Cereb. Blood. Flow. Metab. 2013, 33(5): 708–715. doi: 10.1038/jcbfm.2013.1</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Gooch, J.; Wilcock, D.M. Animal models of vascular cognitive impairment and dementia (VCID). Cell Mol Neurobiol. 2016, 36(2):233-239. doi: 10.1007/s10571-015-0286-3</mixed-citation><mixed-citation xml:lang="en">Gooch, J.; Wilcock, D.M. Animal models of vascular cognitive impairment and dementia (VCID). Cell Mol Neurobiol. 2016, 36(2):233-239. doi: 10.1007/s10571-015-0286-3</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Hattori, Y.; Enmi, J.; Kitamura, A.; Yamamoto, Y.; Saito, S.; Takahashi, Y. A novel mouse model of subcortical infarcts with dementia. J. Neurosci. 2015, 35(9):3915-3928. doi: 10.1523/JNEUROSCI.3970-14.2015</mixed-citation><mixed-citation xml:lang="en">Hattori, Y.; Enmi, J.; Kitamura, A.; Yamamoto, Y.; Saito, S.; Takahashi, Y. A novel mouse model of subcortical infarcts with dementia. J. Neurosci. 2015, 35(9):3915-3928. doi: 10.1523/JNEUROSCI.3970-14.2015</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Neto, C.J.B.F.; Paganelli, R.A.; Benetoli, A.; Lima, K.C.M.; Milani, H. Permanent, 3-stage, 4-vessel occlusion as a model of chronic and progressive brain hypoperfusion in rats: a neurohistological and behavioral analysis. Behav Brain Res. 2005, 160(2):312-322. doi: 10.1016/j.bbr.2004.12.016</mixed-citation><mixed-citation xml:lang="en">Neto, C.J.B.F.; Paganelli, R.A.; Benetoli, A.; Lima, K.C.M.; Milani, H. Permanent, 3-stage, 4-vessel occlusion as a model of chronic and progressive brain hypoperfusion in rats: a neurohistological and behavioral analysis. Behav Brain Res. 2005, 160(2):312-322. doi: 10.1016/j.bbr.2004.12.016</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Jiwa, N.S.; Garrard, P.; Hainsworth, A.H. Experimental models of vascular dementia and vascular cognitive impairment: a systematic review. J. Neurochem. 2010, 115(4):814-828. doi: 10.1111/j.1471-4159.2010.06958.x</mixed-citation><mixed-citation xml:lang="en">Jiwa, N.S.; Garrard, P.; Hainsworth, A.H. Experimental models of vascular dementia and vascular cognitive impairment: a systematic review. J. Neurochem. 2010, 115(4):814-828. doi: 10.1111/j.1471-4159.2010.06958.x</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Niedowicz, D.M.; Reeves, V.L.; Platt, T.L.; Kohler, K.; Beckett, T.L.; Powell, D.K.; Lee, T.L.; Sexton, T.R.; Song, E.S.; Brewer, L.D.; Latimer, C.S.; Kraner, S.D.; Larson, K.L.; Ozcan, S.; Norris, C.M.; Hersh, L.B.; Porter, N.M.; Wilcock, D.M.; Murphy, M.P. Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia. Acta Neuropathol Commun. 2014, 2: 64. doi: 10.1186/2051-5960-2-64</mixed-citation><mixed-citation xml:lang="en">Niedowicz, D.M.; Reeves, V.L.; Platt, T.L.; Kohler, K.; Beckett, T.L.; Powell, D.K.; Lee, T.L.; Sexton, T.R.; Song, E.S.; Brewer, L.D.; Latimer, C.S.; Kraner, S.D.; Larson, K.L.; Ozcan, S.; Norris, C.M.; Hersh, L.B.; Porter, N.M.; Wilcock, D.M.; Murphy, M.P. Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia. Acta Neuropathol Commun. 2014, 2: 64. doi: 10.1186/2051-5960-2-64</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Cognat, E.; Cleophax, S.; Domenga-Denier, V.; Joutel, A. Early white matter changes in CADASIL: evidence of segmental intramyelinic oedema in a pre-clinical mouse model. Acta Neuropathol Commun. 2014, 2:49. doi: 10.1186/2051-5960-2-49</mixed-citation><mixed-citation xml:lang="en">Cognat, E.; Cleophax, S.; Domenga-Denier, V.; Joutel, A. Early white matter changes in CADASIL: evidence of segmental intramyelinic oedema in a pre-clinical mouse model. Acta Neuropathol Commun. 2014, 2:49. doi: 10.1186/2051-5960-2-49</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Neha; Sodhi, R.K.; Jaggi, A.S.; Singh, N. Animal models of dementia and cognitive dysfunction. Life Sci. 2014, 109(2): 73-86. doi: 10.1016/j.lfs.2014.05.017</mixed-citation><mixed-citation xml:lang="en">Neha; Sodhi, R.K.; Jaggi, A.S.; Singh, N. Animal models of dementia and cognitive dysfunction. Life Sci. 2014, 109(2): 73-86. doi: 10.1016/j.lfs.2014.05.017</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang, X.; Le, W. Pathological role of hypoxia in Alzheimer’s disease. Exp Neurol. 2010, 223(2):299-303. doi: 10.1016/j.expneurol.2009.07.033</mixed-citation><mixed-citation xml:lang="en">Zhang, X.; Le, W. Pathological role of hypoxia in Alzheimer’s disease. Exp Neurol. 2010, 223(2):299-303. doi: 10.1016/j.expneurol.2009.07.033</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Malick, M.; Gilbert, K.; Brouillette, J.; Godbout, R.; Rousseau, G. Cognitive deficits following a post-myocardial infarct in the rat are blocked by the serotonin-norepinephrine reuptake inhibitor desvenlafaxine. Int J Mol Sci. 2018, 19(12):3748. doi: 10.3390/ijms19123748</mixed-citation><mixed-citation xml:lang="en">Malick, M.; Gilbert, K.; Brouillette, J.; Godbout, R.; Rousseau, G. Cognitive deficits following a post-myocardial infarct in the rat are blocked by the serotonin-norepinephrine reuptake inhibitor desvenlafaxine. Int J Mol Sci. 2018, 19(12):3748. doi: 10.3390/ijms19123748</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Drake, C.; Boutin, H.; Jones, M.S.; Denes, A.; McColl, B.W.; Selvarajah, J.R.; Hulme, S.; Georgiou, R.F.; Hinz, R.; Gerhard, A.; Vail, A.; Prenant, C.; Julyan, P.; Maroy, R.; Brown, G.; Smigova, A.; Herholz, K.; Kassiou, M.; Crossman, D.; Francis, S.; Proctor, S.D.; Russell, J.C.; Hopkins, S.J.; Tyrrell, P.J.; Rothwell, N.J.; Allan, S.M. Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain Behav Immun. 2011, 25(6):1113-1122. doi: 10.1016/j.bbi.2011.02.008</mixed-citation><mixed-citation xml:lang="en">Drake, C.; Boutin, H.; Jones, M.S.; Denes, A.; McColl, B.W.; Selvarajah, J.R.; Hulme, S.; Georgiou, R.F.; Hinz, R.; Gerhard, A.; Vail, A.; Prenant, C.; Julyan, P.; Maroy, R.; Brown, G.; Smigova, A.; Herholz, K.; Kassiou, M.; Crossman, D.; Francis, S.; Proctor, S.D.; Russell, J.C.; Hopkins, S.J.; Tyrrell, P.J.; Rothwell, N.J.; Allan, S.M. Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain Behav Immun. 2011, 25(6):1113-1122. doi: 10.1016/j.bbi.2011.02.008</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Li, J.G.; Praticò, D. High levels of homocysteine results in cerebral amyloid angiopathy in mice. J Alzheimers Dis. 2015, 43(1): 29-35. doi: 10.3233/JAD-141101</mixed-citation><mixed-citation xml:lang="en">Li, J.G.; Praticò, D. High levels of homocysteine results in cerebral amyloid angiopathy in mice. J Alzheimers Dis. 2015, 43(1): 29-35. doi: 10.3233/JAD-141101</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Sudduth, T.L.; Weekman, E.M.; Brothers, H.M.; Braun, K.; Wilcock, D.M. β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice. Alzheimers Res Ther. 2014, 6(3):32. doi: 10.1186/alzrt262</mixed-citation><mixed-citation xml:lang="en">Sudduth, T.L.; Weekman, E.M.; Brothers, H.M.; Braun, K.; Wilcock, D.M. β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice. Alzheimers Res Ther. 2014, 6(3):32. doi: 10.1186/alzrt262</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Sebastian, M.J.; Khan, S.K.; Pappachan, J.M.; Jeeyavudeen, M.S. Diabetes and cognitive function: An evidence-based current perspective. World J Diabetes 2023, 14(2):92-109. doi: 10.4239/wjd.v14.i2.92.</mixed-citation><mixed-citation xml:lang="en">Sebastian, M.J.; Khan, S.K.; Pappachan, J.M.; Jeeyavudeen, M.S. Diabetes and cognitive function: An evidence-based current perspective. World J Diabetes 2023, 14(2):92-109. doi: 10.4239/wjd.v14.i2.92.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Saedi, E.; Gheini, M.R.; Faiz, F.; Arami, M.A. Diabetes mellitus and cognitive impairments. World J Diabetes 2016, 7(17):412- 422. doi: 10.4239/wjd.v7.i17.412</mixed-citation><mixed-citation xml:lang="en">Saedi, E.; Gheini, M.R.; Faiz, F.; Arami, M.A. Diabetes mellitus and cognitive impairments. World J Diabetes 2016, 7(17):412- 422. doi: 10.4239/wjd.v7.i17.412</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez, J.L.Jr.; Jensen, R.A.; Vasquez, B.J.; Lacob, J.S.; McGaugh, J.L.; Purdy, R.E. Acquisition deficits induced by sodium nitrite in rats and mice. Psychopharmacology (Berl). 1979, 60(3):221–228. doi:10.1007/bf00426659</mixed-citation><mixed-citation xml:lang="en">Martinez, J.L.Jr.; Jensen, R.A.; Vasquez, B.J.; Lacob, J.S.; McGaugh, J.L.; Purdy, R.E. Acquisition deficits induced by sodium nitrite in rats and mice. Psychopharmacology (Berl). 1979, 60(3):221–228. doi:10.1007/bf00426659</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Hansson, G.K.; Hermansson, A. The immune system in atherosclerosis. Nat Immunol. 2011, 12(3):204-212. doi: 10.1038/ni.2001</mixed-citation><mixed-citation xml:lang="en">Hansson, G.K.; Hermansson, A. The immune system in atherosclerosis. Nat Immunol. 2011, 12(3):204-212. doi: 10.1038/ni.2001</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Daugherty, A. Mouse models of atherosclerosis. Am J Med Sci. 2002, 323:3–10. doi: 10.1097/00000441-200201000-00002</mixed-citation><mixed-citation xml:lang="en">Daugherty, A. Mouse models of atherosclerosis. Am J Med Sci. 2002, 323:3–10. doi: 10.1097/00000441-200201000-00002</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Getz, G.S.; Reardon, C.A. Diet and murine atherosclerosis. Arterioscler Thromb Vasc Biol. 2006, 26(2):242-249. doi: 10.1161/01.ATV.0000201071.49029.17</mixed-citation><mixed-citation xml:lang="en">Getz, G.S.; Reardon, C.A. Diet and murine atherosclerosis. Arterioscler Thromb Vasc Biol. 2006, 26(2):242-249. doi: 10.1161/01.ATV.0000201071.49029.17</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
