ppanPersonalized Psychiatry and NeurologyPersonalized Psychiatry and Neurology2712-9179V. M. Bekhterev National Medical Research Centre for Psychiatry and Neurology of the Ministry of Health of the Russian Federation (Bekhterev NMRC PN)10.52667/2712-9179-2024-4-3-12-23ppan-108Research ArticleREVIEWNeutrophil-to-Lymphocyte Ratio Any Association with Metabolic Syndrome in SchizophreniaZakharovaN. V.

Natalia V. Zakharova

192019 Saint Petersburg

NasyrovaR. F.

 Regina F. Nasyrova

192019 Saint Petersburg

regina_nmrcpn@mail.ruRakhmatullinA. I.

Artyom I. Rakhmatullin

192019 Saint Petersburg

 

RumiantcevaM. N.

Maria N. Rumiantceva

190121 Saint Petersburg

SizykhK. I.

Kirill I. Sizykh

197341 Saint Petersburg

KostinF. N.

Fedor N. Kostin - Independent researcher

Saint Petersburg

V. M. Bekhterev National Medical Research Center for Psychiatry and NeurologyRussian FederationSt. Nicholas Psychiatric hospitalRussian FederationAlmazov National Medical Research CentreRussian Federation202418092024431223Copyright © Zakharova N.V., Nasyrova R.F., Rakhmatullin A.I., Rumiantceva M.N., Sizykh K.I., Kostin F.N., 20242024Zakharova N.V., Nasyrova R.F., Rakhmatullin A.I., Rumiantceva M.N., Sizykh K.I., Kostin F.N.Zakharova N.V., Nasyrova R.F., Rakhmatullin A.I., Rumiantceva M.N., Sizykh K.I., Kostin F.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jppn.ru/jour/article/view/108

To date, hematologic inflammation coefficients (HICs) have been considered as biological markers linking the functions of the immune, endocrine, and autonomous nervous systems. HICs are markers of immune abnormalities that accompany various pathologic conditions and, to a large extent, determine disease prognosis, survival time, and function. According to the results of a meta-analysis covering the results of examination of more than 168 thousand patients, it was found that the ratio of neutrophils to lymphocytes (NLR) is associated with higher levels in patients with metabolic syndrome and can potentially be used for early detection of this pathology. Given these facts, it seems reasonable to test the assumption of the role of HICs in the pathogenesis of psychiatric disorders, their participation in the mechanisms of development of comorbid conditions, or predicting the outcome and effects of therapy. In 2024, the team of the Bekhterev Center began to perform work under the state assignment of the Ministry of Health of the Russian Federation, the purpose of which was to develop and validate a model for predicting individual risks of metabolic disorders in patients with psychiatric disorders, on the basis of which interpretive software will be presented. The team of authors of this article focused on conducting a systematic review of publications to test this hypothesis.

neutrophil-to-lymphocyte ratio (NLR)schizophreniametabolic syndromehematologic inflammation coefficients (HICs)systemic inflammationpsychiatric disordersimmune dysregulationbiomarkersantipsychotic therapypsychoneuroimmunologyThe authors are grateful to the administration and management of the V. M. Bekhterev National Medical Research Centre for Psychiatry and Neurology and also thank the Director of the Centre, Scientific Head of the Geriatric Psychiatry Department of the Centre, Doctor of Medical Sciences, Professor N. G. Neznanov for the opportunity to conduct this project.ReferencesZahorec, R. Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001, 1:5–14.Zahorec, R. Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001, 1:5–14.Firment, J.; Hulin, I. 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The authors declare that there are no conflicts of interest present.