ppanPersonalized Psychiatry and NeurologyPersonalized Psychiatry and Neurology2712-9179V. M. Bekhterev National Medical Research Centre for Psychiatry and Neurology of the Ministry of Health of the Russian Federation (Bekhterev NMRC PN)10.52667/2712-9179-2024-4-2-25-31ppan-101Research ArticleREVIEWLimitations of the Use of Animal Models of Acute Myocardial Infarction for Experimental Studies of Vascular Cognitive Dysfunction: Brief ReviewPetrovA. V.

Artem V. Petrov

660022 Krasnoyarsk

EvsyukovA. A.

Aleksandr A. Evsyukov

660022 Krasnoyarsk

PetrovaM. M.

Marina M. Petrova 

660022 Krasnoyarsk

stk99@yandex.ruShnayderN. A.

Natalia A. Shnayder

660022 Krasnoyarsk; 192019 Saint Petersburg

V.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation202418062024422531Copyright © Petrov A.V., Evsyukov A.A., Petrova M.M., Shnayder N.A., 20242024Petrov A.V., Evsyukov A.A., Petrova M.M., Shnayder N.A.Petrov A.V., Evsyukov A.A., Petrova M.M., Shnayder N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jppn.ru/jour/article/view/101

This brief review presents Russian and foreign models of acute myocardial infarction (AMI), which are used to gain new knowledge about the pathophysiology of the development of this disease, as well as to search for sensitive and specific biomarkers of AMI and associated pathologies, including vascular cognitive disorders. However, modeling vascular cognitive disorders associated with AMI is a challenging task. Re-searchers need to take into account the additive effect of ischemia of striated muscles (myocardium or skeletal muscles) and central anesthetics during the simulation of AMI in experimental animals.

fundamental cardiologyfundamental neurologyexperimentanimal modelacute myocardial infarctiondisease modelingratThe study was carried out within the framework of the state assignment of the V.F. VoinoYasenetsky Krasnoyarsk State Medical University National of the Ministry of Health of Russia 2022 - 2025 (“Development of a personalized algorithm for diagnosing vascular moderate cognitive dysfunction against the background of acute myocardial infarction based on new genetic and biochemical biomarkers”, No. 123022800057-6).ReferencesAcute myocardial infarction with ST segment elevation electrocardiograms: Clinical recommendations. Association of Cardiovascular Surgeons of Russia. 2020 https://www.monikiweb.ru/sites/default/files/page_content_files/KP157.pdf. (In Russian) .Acute myocardial infarction with ST segment elevation electrocardiograms: Clinical recommendations. Association of Cardiovascular Surgeons of Russia. 2020 https://www.monikiweb.ru/sites/default/files/page_content_files/KP157.pdf. (In Russian) .World Health Organization. https://www.who.int/ru/news-room/fact-sheets/detail/the-top-10-causes-of-death. 2020.World Health Organization. https://www.who.int/ru/news-room/fact-sheets/detail/the-top-10-causes-of-death. 2020.Kosolapov, V. P., Yarmonova M. V. The analysis of high cardiovascular morbidity and mortality in the adult population as a medical and social problem and the search for ways to solve it. Ural medical journal. 2021. Vol. 20 (1) 58-64. htpps://doi org/ 10.52420/2071- 5943-2021-20-1-58-64. (In Russian)Kosolapov, V. P., Yarmonova M. V. The analysis of high cardiovascular morbidity and mortality in the adult population as a medical and social problem and the search for ways to solve it. Ural medical journal. 2021. Vol. 20 (1) 58-64. htpps://doi org/ 10.52420/2071- 5943-2021-20-1-58-64. (In Russian)Federal State Statistics Service. https://rosstat.gov.ru (In Russian)Federal State Statistics Service. https://rosstat.gov.ru (In Russian)Ngo Bilong Ekedi Anzh Veronik , Akselrod A.S., Shchekochikhin D.Iu., Tebenkova E.S., Zhelankin A.V., Stonogina D.A., Syrkina E.A., Ternovoy S.K. Contemporary diagnostic algorithm for coronary artery disease: achievements and prospects. Russian Journal of Cardiology and Cardiovascular Surgery. 2019;12(5):418 428. https://doi.org/10.17116/kardio201912051418. (In Russian)Ngo Bilong Ekedi Anzh Veronik , Akselrod A.S., Shchekochikhin D.Iu., Tebenkova E.S., Zhelankin A.V., Stonogina D.A., Syrkina E.A., Ternovoy S.K. Contemporary diagnostic algorithm for coronary artery disease: achievements and prospects. Russian Journal of Cardiology and Cardiovascular Surgery. 2019;12(5):418 428. https://doi.org/10.17116/kardio201912051418. (In Russian)Zimnitskaya O.V., Petrova M.M., Lareva N.V., Cherniaeva M.S., Al-Zamil M., Ivanova A.E., Shnayder N.A. Leukocyte telo-mere length as a molecular biomarker of coronary heart disease. Genes 2022, 13, 1234. https://doi.org/10.3390/genes13071234Zimnitskaya O.V., Petrova M.M., Lareva N.V., Cherniaeva M.S., Al-Zamil M., Ivanova A.E., Shnayder N.A. Leukocyte telo-mere length as a molecular biomarker of coronary heart disease. Genes 2022, 13, 1234. https://doi.org/10.3390/genes13071234Graff-Radford J. Vascular cognitive impairment. Continuum. Minneap Minn. 2019; 25(1): 147-164. https://doi.org/10.1212/CON.0000000000000684.Graff-Radford J. Vascular cognitive impairment. Continuum. Minneap Minn. 2019; 25(1): 147-164. https://doi.org/10.1212/CON.0000000000000684.Chaulin A.M., Duplyakov D.V. Biomarkers of acute myocardial infarction: Diagnostic and prognostic value. Part 2 (Liter-ature Review). Journal of Clinical Practice. 2020, 11(4): 70–82. https://doi.org/10.17816/clinpract48893Chaulin A.M., Duplyakov D.V. Biomarkers of acute myocardial infarction: Diagnostic and prognostic value. Part 2 (Liter-ature Review). Journal of Clinical Practice. 2020, 11(4): 70–82. https://doi.org/10.17816/clinpract48893Chaulin A.M., Abashina O.E., Duplyakov D.V. High-sensitivity cardiac troponins: detection and central analytical charac-teristics. Cardiovascular Therapy and Prevention. 2021; 20(2): 2590. https://doi.org/10.15829/1728-8800-2021-Chaulin A.M., Abashina O.E., Duplyakov D.V. High-sensitivity cardiac troponins: detection and central analytical charac-teristics. Cardiovascular Therapy and Prevention. 2021; 20(2): 2590. https://doi.org/10.15829/1728-8800-2021-Jarolim P. High sensitivity cardiac troponin assays in the clinical laboratories. Clinical Chemistry and Laboratory Medicine (CCLM). 2015; 53(5): 635-652. https://doi.org/10.1515/cclm-2014-0565Jarolim P. High sensitivity cardiac troponin assays in the clinical laboratories. Clinical Chemistry and Laboratory Medicine (CCLM). 2015; 53(5): 635-652. https://doi.org/10.1515/cclm-2014-0565Singh V., Martinezclark P., Pascual M., Shaw E.S., O'Neill W.W. Cardiac biomarkers - the old and the new: a review. Coro-nary Arteries Dis. 2010, 21(4): 244-256. https://doi.org/10.1097/MCA.0b013e328338cd1f.Singh V., Martinezclark P., Pascual M., Shaw E.S., O'Neill W.W. Cardiac biomarkers - the old and the new: a review. Coro-nary Arteries Dis. 2010, 21(4): 244-256. https://doi.org/10.1097/MCA.0b013e328338cd1f.Wang J., Bo H., Meng X., Wu Y., Bao Y., Li Y. A simple and fast experimental model of myocardial infarction in the mouse. Tex Heart Inst J. 2006;33(3):290-293.Wang J., Bo H., Meng X., Wu Y., Bao Y., Li Y. A simple and fast experimental model of myocardial infarction in the mouse. Tex Heart Inst J. 2006;33(3):290-293.Martin T.P., MacDonald E.A., Elbassioni A.A.M., O'Toole D., Zaeri A.A.I., Nicklin S.A., Gray G.A., Loughrey C.M. Preclinical models of myocardial infarction: from mechanism to translation. Br J Pharmacol. 2022; 179(5): 770-791. https://doi.org/10.1111/bph.15595Martin T.P., MacDonald E.A., Elbassioni A.A.M., O'Toole D., Zaeri A.A.I., Nicklin S.A., Gray G.A., Loughrey C.M. Preclinical models of myocardial infarction: from mechanism to translation. Br J Pharmacol. 2022; 179(5): 770-791. https://doi.org/10.1111/bph.15595Verdouw P.D., van den Doel M.A., de Zeeuw S.., Duncker DJ. Animal models in the study of myocardial ischaemia and is-chaemic syndromes. Cardiovasc Res. 1998; 39(1): 121-135. https://doi.org/10.1016/s0008-6363(98)00069-8Verdouw P.D., van den Doel M.A., de Zeeuw S.., Duncker DJ. Animal models in the study of myocardial ischaemia and is-chaemic syndromes. Cardiovasc Res. 1998; 39(1): 121-135. https://doi.org/10.1016/s0008-6363(98)00069-8Chimenti S., Carlo E., Masson S., Bai A., Latini R. Myocardial infarction: animal models. Methods Mol Med. 2004; 98: 217-226. https://doi.org/10.1385/1-59259-771-8:217Chimenti S., Carlo E., Masson S., Bai A., Latini R. Myocardial infarction: animal models. Methods Mol Med. 2004; 98: 217-226. https://doi.org/10.1385/1-59259-771-8:217Voronov D.A., Garilenko A.V., Bochkov N.P. Stimulation of angiogenesis improves the results of surgical treatment of lover limb ischemia: experimental study and clinical effectiveness. Cardiology and cardiovascular surgery. 2009; 2: 3: 45-49. (In Russian)Voronov D.A., Garilenko A.V., Bochkov N.P. Stimulation of angiogenesis improves the results of surgical treatment of lover limb ischemia: experimental study and clinical effectiveness. Cardiology and cardiovascular surgery. 2009; 2: 3: 45-49. (In Russian)Petrishchev N. N., Mikhailova I.A. Laser-induced microvascular thrombosis St. Petersburg.: St. Petersburg State Medical University. 2001: 87. (In Russian)Petrishchev N. N., Mikhailova I.A. Laser-induced microvascular thrombosis St. Petersburg.: St. Petersburg State Medical University. 2001: 87. (In Russian)Waterman R.S., Betancourt A.M. Treating chronic pain with mesenchymal stem cells: A therapeutic approach worthy of continued investigation. J Stem Cell Res Ther . 2011; S2:001. https://doi.org:10.4172/2157-7633.S2-001.Waterman R.S., Betancourt A.M. Treating chronic pain with mesenchymal stem cells: A therapeutic approach worthy of continued investigation. J Stem Cell Res Ther . 2011; S2:001. https://doi.org:10.4172/2157-7633.S2-001.Elmali N, Esenkaya I, Karadağ N, Taş F, Elmali N. Effects of resveratrol on skeletal muscle in ischemia-reperfusion injury. Ulus Travma Acil Cerrahi Derg. 2007;13(4):274-80. PMID: 17978908Elmali N, Esenkaya I, Karadağ N, Taş F, Elmali N. Effects of resveratrol on skeletal muscle in ischemia-reperfusion injury. Ulus Travma Acil Cerrahi Derg. 2007;13(4):274-80. PMID: 17978908Nevzorova V.A., Chertok V.M., Brodskaya T.A., Roshchenko R.V., Plekhova N.G. Experimental modeling of myocardial infarction in old rats. Pacific Medical Journal. 2022;2:72–74. https://doi.org/10.34215/1609-1175-2022-2-72-74. (In Russian)Nevzorova V.A., Chertok V.M., Brodskaya T.A., Roshchenko R.V., Plekhova N.G. Experimental modeling of myocardial infarction in old rats. Pacific Medical Journal. 2022;2:72–74. https://doi.org/10.34215/1609-1175-2022-2-72-74. (In Russian)Kogan A.Kh. Simulation of myocardial infarction. – Moscow., 1979. 30. (In Russian)Kogan A.Kh. Simulation of myocardial infarction. – Moscow., 1979. 30. (In Russian)Selye H., Bajusz E., Grasso S., Mendell P. Simple techniques for the surgical occlusion of coronary vessels in the rat. Angi-ology. 1960;11:398-407. https://doi.org/10.1177/000331976001100505Selye H., Bajusz E., Grasso S., Mendell P. Simple techniques for the surgical occlusion of coronary vessels in the rat. Angi-ology. 1960;11:398-407. https://doi.org/10.1177/000331976001100505Nikulina N.A., Dotsenko E.A., Nerovnya A.M., Salivonchik D.P., Platoshkin E.N., Nikolaeva N.V., Tishkov S.P. Experi-mental myocardial infarction in rats: features of modeling and course within the first 48 hours after ligation of the coronary artery. Problems of Health and Ecology. 2020, 64(2): 91-96. (In Russian)Nikulina N.A., Dotsenko E.A., Nerovnya A.M., Salivonchik D.P., Platoshkin E.N., Nikolaeva N.V., Tishkov S.P. Experi-mental myocardial infarction in rats: features of modeling and course within the first 48 hours after ligation of the coronary artery. Problems of Health and Ecology. 2020, 64(2): 91-96. (In Russian)Mohamed S.A., Fares K.M., Hasan-Ali H., Bakry R. The effect of anesthetic technique on cardiac troponin-T and systemic inflammatory response after major abdominal cancer surgery. J Anesthe Clinic Res. 2013; 4: 296. https://doi.org/10.4172/2155-6148.1000296Mohamed S.A., Fares K.M., Hasan-Ali H., Bakry R. The effect of anesthetic technique on cardiac troponin-T and systemic inflammatory response after major abdominal cancer surgery. J Anesthe Clinic Res. 2013; 4: 296. https://doi.org/10.4172/2155-6148.1000296Ishikawa M., Iwasaki M., Sakamoto A. Ma D. Anesthetics may modulate cancer surgical outcome: a possible role of miRNAs regulation. BMC Anesthesiol. 2021, 21: 71. https://doi.org/10.1186/s12871-021-01294-wIshikawa M., Iwasaki M., Sakamoto A. Ma D. Anesthetics may modulate cancer surgical outcome: a possible role of miRNAs regulation. BMC Anesthesiol. 2021, 21: 71. https://doi.org/10.1186/s12871-021-01294-wMarchegiani F., Matacchione G., Ramini D., Marcheselli F., Recchioni R., Casoli T., Mercuri E., Lazzarini M., Giorgetti B., Cameriere V., Paolini S., Paciaroni L., Rossi T., Galeazzi R., Lisa R., Bonfigli A.R., Procopio A.D., De Luca M., Pelliccioni G., Olivieri F. Diagnostic performance of new and classic CSF biomarkers in age-related dementias. Aging (Albany NY). 2019;11(8):2420-2429. https://doi.org/10.18632/aging.101925.Marchegiani F., Matacchione G., Ramini D., Marcheselli F., Recchioni R., Casoli T., Mercuri E., Lazzarini M., Giorgetti B., Cameriere V., Paolini S., Paciaroni L., Rossi T., Galeazzi R., Lisa R., Bonfigli A.R., Procopio A.D., De Luca M., Pelliccioni G., Olivieri F. Diagnostic performance of new and classic CSF biomarkers in age-related dementias. Aging (Albany NY). 2019;11(8):2420-2429. https://doi.org/10.18632/aging.101925.Tabnak P., Masrouri S., Geraylow K.R., Zarei M., Esmailpoor Z.H. Targeting miRNAs with anesthetics in cancer: Current understanding and future perspectives. Biomed Pharmacother. 2021 Dec;144:112309. doi: https://doi.org/10.1016/j.biopha.2021.112309Tabnak P., Masrouri S., Geraylow K.R., Zarei M., Esmailpoor Z.H. Targeting miRNAs with anesthetics in cancer: Current understanding and future perspectives. Biomed Pharmacother. 2021 Dec;144:112309. doi: https://doi.org/10.1016/j.biopha.2021.112309Shnayder N.A. Postoperative cognitive dysfunction. Neurological Journal. 2005, 10(4): 37-43, (In Russian)Shnayder N.A. Postoperative cognitive dysfunction. Neurological Journal. 2005, 10(4): 37-43, (In Russian)Shnayder N.A., Salmina A.B. Biochemical and molecular mechanisms of pathogenesis of postoperative cognitive dysfunc-tion/ Neurological Journal. 2007, 2: 1-7. (In Russian)Shnayder N.A., Salmina A.B. Biochemical and molecular mechanisms of pathogenesis of postoperative cognitive dysfunc-tion/ Neurological Journal. 2007, 2: 1-7. (In Russian)Li G.F., Li Z.B., Zhuang S.J., Li G.C. Inhibition of microRNA-34a protects against propofol anesthesia-induced neurotoxicity and cognitive dysfunction via the MAPK/ERK signaling pathway. Neurosci Lett. 2018; 675: 152-159. https://doi.org/10.1016/j.neulet.2018.03.052Li G.F., Li Z.B., Zhuang S.J., Li G.C. Inhibition of microRNA-34a protects against propofol anesthesia-induced neurotoxicity and cognitive dysfunction via the MAPK/ERK signaling pathway. Neurosci Lett. 2018; 675: 152-159. https://doi.org/10.1016/j.neulet.2018.03.052Yu Y., Liu H., Yang D., He F., Yuan Y., Guo J., Hu J., Yu J., Yan X., Wang S., Du Z. Aloe-emodin attenuates myocardial infarc-tion and apoptosis via up-regulating miR-133 expression. Pharmacol Res. 2019;146:104315. https://doi.org/10.1016/j.phrs.2019.104315Yu Y., Liu H., Yang D., He F., Yuan Y., Guo J., Hu J., Yu J., Yan X., Wang S., Du Z. Aloe-emodin attenuates myocardial infarc-tion and apoptosis via up-regulating miR-133 expression. Pharmacol Res. 2019;146:104315. https://doi.org/10.1016/j.phrs.2019.104315Singh G.B., Cowan D.B., Wang D.Z. Tiny regulators of massive tissue: microRNAs in skeletal muscle development, myopa-thies, and cancer cachexia. Front Oncol. 2020; 10: 598964. https://doi.org/10.3389/fonc.2020.598964Singh G.B., Cowan D.B., Wang D.Z. Tiny regulators of massive tissue: microRNAs in skeletal muscle development, myopa-thies, and cancer cachexia. Front Oncol. 2020; 10: 598964. https://doi.org/10.3389/fonc.2020.598964European convention for the protection of vertebrate animals used for experimental and other scientific purposes (Council of Europe, Strasbourg 18.03.1986), ETS N 123 appendix A. 2010. https://rm.coe.int/168007a67bEuropean convention for the protection of vertebrate animals used for experimental and other scientific purposes (Council of Europe, Strasbourg 18.03.1986), ETS N 123 appendix A. 2010. https://rm.coe.int/168007a67b

The authors declare that there are no conflicts of interest present.