ppanPersonalized Psychiatry and NeurologyPersonalized Psychiatry and Neurology2712-9179V. M. Bekhterev National Medical Research Centre for Psychiatry and Neurology of the Ministry of Health of the Russian Federation (Bekhterev NMRC PN)10.52667/2712-9179-2024-4-2-13-24ppan-100Research ArticleREVIEWHyperexpression of Proinflammatory Cytokines in Blood as a Biomarker of Systemic Inflammatory Response in Schizophrenia: Scoping ReviewShnayderN. A.

Natalia A. Shnayder

192019, St.Petersburg

naschnaider@yandex.ruRusanovaG. V.

Galina V. Rusanova

192019, St.Petersburg

rusanovaGV@yandex.ruNasyrovaR. F.

Regina F. Nasyrova

192019, St.Petersburg

regina_nmrcpn@mail.ruV. M. Bekhterev National Medical Research Centre for Psychiatry and NeurologyRussian Federation202418062024421324Copyright © Shnayder N.A., Rusanova G.V., Nasyrova R.F., 20242024Shnayder N.A., Rusanova G.V., Nasyrova R.F.Shnayder N.A., Rusanova G.V., Nasyrova R.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jppn.ru/jour/article/view/100

Introduction: An imbalance of the genetically determined cytokine response plays a key role in the etiology of treatment-resistant schizophrenia (TRS). In recent years, an attempt has been made to evaluate the prognostic role of systemic inflammation in the development of TRS.  The problem requires a multidisciplinary approach on the part of the specialists in the following clinical disciplines: psychiatry, immunology, experimental medicine and pharmacogenetics. The solution of this problem is possible with the involvement of preventive and personalized medicine. The purpose: Evaluation the prognostic role of genetic polymorphisms of pro-inflammatory cytokines in the development of TRS. Materials and Methods: We conducted a keyword-based analysis of the English and Russian-language articles published within the past 5 years. The following databases were used in the study: PubMed, MedLine, Web of Science Core Collection (Clarivate Analytics), Web Science, Russian Science Citation Index, Scopus, Scientific Research, Google Scholar, Oxford Press, and eLibrary. Results: In a number of the analyzed works, an increased level of pro-inflammatory cytokine production was noted in patients with TRS. Based on this, single nucleotide variants (SNVs), their influence on the expression of pro- and anti-inflammatory cytokine genes, as well as their predictor role in the development of TRS. The most promising SNVs for further studies were identified. Conclusion: The risk of developing TRS is associated with a genetically determined status of the cytokine response and its regulation. Studies of the association of various SNVs of genes encoding pro-inflammatory cytokines in the Russian Federation need to be continued.

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The authors declare that there are no conflicts of interest present.