ppanPersonalized Psychiatry and NeurologyPersonalized Psychiatry and Neurology2712-9179V. M. Bekhterev National Medical Research Centre for Psychiatry and Neurology of the Ministry of Health of the Russian Federation (Bekhterev NMRC PN)10.52667/2712-9179-2021-1-1-46-53ppan-10Research ArticleREVIEWCandidate genes of empty sellaSharaviiV. B.

Victoria B. Sharavii

119991, Moscow, tel.: +79940029712

victoriasharavii@gmail.comShnayderN. A.

Natalia A. Shnayder

192019, St.Petersburg; 660022, Krasnoyarsk

nataliash-nayder@gmail.comPetrovaM. M.

Marina M. Petrova

660022, Krasnoyarsk

stk99@yandex.ruI.M. Sechenov First Moscow State Medical UniversityRussian FederationV.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology; V. F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityRussian FederationV.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation202115052021114653Copyright © Sharavii V.B., Shnayder N.A., Petrova M.M., 20212021Sharavii V.B., Shnayder N.A., Petrova M.M.Sharavii V.B., Shnayder N.A., Petrova M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jppn.ru/jour/article/view/10

Empty sella (ES) is a condition characterized by arachnoid herniation into the sellar fossa which leads to flattening of the pituitary gland against the sellar floor. Besides endocrine disturbances, patients with ESS may also have neuropsychiatric symptoms such as headache, dizziness, seizures, schizophrenia. Typically, ES is not inherited. However, due to the advent of new methods of brain imaging and molecular genetics, the perspective on the genetics of ESS has been changing. The aim of this study is to analyze genome-wide association studies of candidate genes related to the development of ESS in humans. Based on the available studies which have been analyzed, all candidate genes of ESS were divided into 4 groups: group 1 - candidate genes related to ESS, group 2 - candidate genes related to pathways of ESS, group 3 - candidate genes related to cellular components of ESS, group 4 - candidate genes related to biological processes of ESS.

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The authors declare that there are no conflicts of interest present.